Reference Report

Reference
Citation	Céspedes, M.A., Galindo, M.I., Couso, J.P. (2010). Dioxin Toxicity In Vivo Results from an Increase in the Dioxin-Independent Transcriptional Activity of the Aryl Hydrocarbon Receptor. PLoS ONE 5(11): e15382. (Export to RIS)
FlyBase ID	FBrf0212269
Publication Type	Research paper
PubMed ID	21079739
PubMed Abstract	The Aryl hydrocarbon receptor (Ahr) is the nuclear receptor mediating the toxicity of dioxins--widespread and persistent pollutants whose toxic effects include tumor promotion, teratogenesis, wasting syndrome and chloracne. Elimination of Ahr in mice eliminates dioxin toxicity but also produces adverse effects, some seemingly unrelated to dioxin. Thus the relationship between the toxic and dioxin-independent functions of Ahr is not clear, which hampers understanding and treatment of dioxin toxicity. Here we develop a Drosophila model to show that dioxin actually increases the in vivo dioxin-independent activity of Ahr. This hyperactivation resembles the effects caused by an increase in the amount of its dimerisation partner Ahr nuclear translocator (Arnt) and entails an increased transcriptional potency of Ahr, in addition to the previously described effect on nuclear translocation. Thus the two apparently different functions of Ahr, dioxin-mediated and dioxin-independent, are in fact two different levels (hyperactivated and basal, respectively) of a single function.
DOI	10.1371/journal.pone.0015382
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Language of Publication	English
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Publication Type	Journal
Abbreviation	PLoS ONE
Title	PLoS ONE
Publication Year	2006-
ISBN/ISSN	1932-6203
Data from Reference
Alleles (13)
	Ecol\lacZ^{BgB0.6+XRE.hs} Mmus\Ahr^Scer\UAS.cCa Mmus\Ahr^{Scer\UAS.T:Avic\GFP-EGFP} Scer\GAL4^GMR.PU Scer\GAL4^rn-GAL4 ss^abr ss^Scer\UAS.cCa ss^{Scer\UAS.T:Avic\GFP-EGFP} ss^sta T:Avic\GFP^EGFP tgo^Scer\UAS.cWa Vvvv\Arnt^Scer\UAS.cCa w^+mC
Constructs (9)
	P{GawB} P{GMR-GAL4.U} P{hs-lacZ.BgB0.6+XRE} P{UAS-Ahr.C} P{UAS-Ahr.EGFP} P{UAS-Arnt.C} P{UAS-ss.C} P{UAS-ss.EGFP} P{UAS-tgo.W}
Genes (9)
	B dac Ecol\lacZ Mmus\Ahr Scer\GAL4 ss tgo Vvvv\Arnt w
Insertions (1)
	P{GawB}rn^GAL4
Natural transposons (1)
	P-element