Reference Report

Reference
Citation	Yagi, Y., Nishida, Y., Ip, Y.T. (2010). Functional analysis of Toll-related genes in Drosophila. Dev. Growth Differ. 52(9): 771--783. (Export to RIS)
FlyBase ID	FBrf0212564
Publication Type	Research paper
PubMed ID	21158756
PubMed Abstract	The Drosophila genome encodes a total of nine Toll and related proteins. The immune and developmental functions of Toll and 18Wheeler (18W) have been analyzed extensively, while the in vivo functions of the other Toll-related proteins require further investigation. We performed transgenic experiments and found that overexpression of Toll-related genes caused different extents of lethality and developmental defects. Moreover, 18w, Toll-6, Toll-7 and Toll-8 often caused related phenotypic changes, consistent with the idea that these four genes have more conserved molecular structure and thus may regulate similar processes in vivo. Deletion alleles of Toll-6, Toll-7 and Toll-8 were generated by targeted homologous recombination or P element excision. These mutant alleles were viable, fertile, and had no detectable defect in the inducible expression of antimicrobial peptide genes except for the Toll-8 mutant had some defects in leg development. The expression of 18w, Toll-7 and Toll-8 mRNA showed wide and overlapping patterns in imaginal discs and the 18w, Toll-8 double and Toll-7, Toll-8 double mutants showed substantially increased lethality. Overall our results suggest that some of the Toll-related proteins, such as 18W, Toll-7 and Toll-8, may have redundant functions in regulating developmental processes.
DOI	10.1111/j.1440-169X.2010.01213.x
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Secondary IDs
Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Dev. Growth Differ.
Title	Development, Growth and Differentiation
Publication Year	1969-
ISBN/ISSN	0012-1592
Data from Reference
Aberrations (4)
	Df(2R)BSC22 Df(3L)Brd6 Df(3L)Brd15 Df(3L)ED218
Alleles (29)
	18w^g.Scer\UAS 18w^k02701 18w^Δ7-35 MstProx^Scer\UAS.cYa Myd88^EP2133 pll^Scer\UAS.cYa Scer\GAL4^32B Scer\GAL4^71B Scer\GAL4^da.G32 Scer\GAL4^dpp.PS Scer\GAL4^e22c Scer\GAL4^GMR.PF Scer\GAL4^lz-gal4 Scer\GAL4^ptc-559.1 Tehao^Scer\UAS.cYa Tl^{C781Y.Scer\UAS} Tl^Scer\UAS.cHa Toll-4^Scer\UAS.cYa Toll-6^ex13 Toll-6^ex70 Toll-6^GS11682 Toll-6^Scer\UAS.cYa Toll-7^g1-1 Toll-7^Scer\UAS.cYa Toll-9^Scer\UAS.cYa Tollo⁵⁸ Tollo⁵⁹ Tollo^EY01776 Tollo^Scer\UAS.cYa
Constructs (16)
	P{dpp-GAL4.PS} P{EPgy2} P{GAL4-da.G32} P{GAL4-ninaE.GMR} P{GSV6} P{UAS-18w.g} P{UAS-MstProx.Y} P{UAS-pll.Y} P{UAS-Tehao.Y} P{UAS-Tl.C781Y} P{UAS-Tl.H} P{UAS-Toll-4.Y} P{UAS-Toll-6.Y} P{UAS-Toll-7.Y} P{UAS-Toll-9.Y} P{UAS-Tollo.Y}
Genes (16)
	18w AttA Dpt Drs MstProx Mtk Myd88 pll Scer\GAL4 Tehao Tl Toll-4 Toll-6 Toll-7 Toll-9 Tollo
Insertions (9)
	P{en2.4-GAL4}e22c P{EP}Myd88^EP2133 P{EPgy2}Tollo^EY01776 P{GawB}32B P{GawB}71B P{GawB}lz^gal4 P{GawB}ptc^559.1 P{GSV6}Toll-6^GS11682 P{lacW}18w^k02701
Natural transposons (1)
	P-element