Reference Report

Reference
Citation	Marinho, J., Casares, F., Pereira, P.S. (2011). The Drosophila Nol12 homologue viriato is a dMyc target that regulates nucleolar architecture and is required for dMyc-stimulated cell growth. Development 138(2): 349--357. (Export to RIS)
FlyBase ID	FBrf0212565
Publication Type	Research paper
PubMed ID	21177347
PubMed Abstract	The nucleolus is a subnuclear factory, the activity of which is required beyond ribosome biogenesis for the regulation of cell growth, death and proliferation. In both Drosophila and mammalian cells, the activity of the nucleolus is regulated by the proto-oncogene Myc. Myc induces the transcription of genes required for ribosome biogenesis and the synthesis of rRNA by RNA polymerase I, a nucleolar event that is rate limiting for cell growth. Here, we show that the fruit fly Nol12 homologue Viriato is a key determinant of nucleolar architecture that is required for tissue growth and cell survival during Drosophila development. We further show that viriato expression is controlled by Drosophila Myc (dMyc), and that the ability of dMyc to stimulate nucleolar and cellular growth depends on viriato expression. Therefore, viriato acts downstream of dMyc to ensure a coordinated nucleolar response to dMyc-induced growth and, thereby, normal organ development.
DOI	10.1242/dev.054411
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Secondary IDs
Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (1)
	Df(3L)H99
Alleles (23)
	Avic\GFP^Scer\UAS.cUa BacA\p35^Scer\UAS.cHa bsk^DN.Scer\UAS Dcr-2^Scer\UAS.cDa dm⁴ dm^Scer\UAS.cZa Ecol\lacZ^rpr.11 Ecol\lacZ^Scer\UAS.cBa Hsap\NOL12^{Scer\UAS.T:Avic\GFP} Nopp140^{True.hs.T:Avic\GFP} p53^5A-1-4 p53^{R155H.Scer\UAS.Ex} Scer\GAL4^Act5C.PI Scer\GAL4^ey.PU Scer\GAL4^hs.PB Scer\GAL4^ptc-559.1 Scer\GAL4^{Scer\FRT.Act5C} Scer\GAL4^Ubi vito^e03237 vito^GD10890 vito^KK111866 vito^Scer\UAS.cMa vito^{Scer\UAS.T:Avic\GFP}
Constructs (19)
	P{Act5C-GAL4} P{AyGAL4} P{ey-GAL4.U} P{GAL4-Hsp70.PB} P{GD10890} P{hs-Nopp140.True.GFP} P{KK111866} P{rpr-lacZ.R.11} P{UAS-bsk.DN} P{UAS-Dcr-2.D} P{UAS-dm.Z} P{UAS-GFP.U} P{UAS-lacZ.B} P{UAS-NOL12.GFP} P{UAS-p35.H} P{UAS-p53.R155H.Ex} P{UAS-vito.GFP} P{UAS-vito.M} P{Ubi-GAL4}
Genes (18)
	Avic\GFP BacA\p35 bsk Dcr-2 dm Ecol\lacZ Fib Hsap\NOL12 Nop60B Nopp140 p53 puc RpI135 rpr Scer\GAL4 T:Avic\GFP Tif-IA vito
Insertions (4)
	P{GawB}ptc^559.1 P{GD10890}v34548 P{KK111866}VIE-260B PBac{RB}vito^e03237
Natural transposons (1)
	P-element