Reference Report

Reference
Citation	Bredendiek, N., Hütte, J., Steingräber, A., Hatt, H., Gisselmann, G., Neuhaus, E.M. (2011). Go α is involved in sugar perception in Drosophila. Chem. Senses 36(1): 69--81. (Export to RIS)
FlyBase ID	FBrf0212580
Publication Type	Research paper
PubMed ID	20940344
PubMed Abstract	Detection of chemical compounds in food sources is based on the activation of 7 transmembrane gustatory receptors (GRs) in mammals and in insects such as Drosophila, although the receptors are not conserved between the classes. Different combinations of Drosophila GRs are involved in the detection of sugars, but the activated signaling cascades are largely unknown. Because 7 transmembrane receptors usually couple to G-proteins, we tried to unravel the intracellular signaling cascade in taste neurons by screening heterotrimeric G-protein mutant flies for gustatory deficits. We found the subunit Goα to be involved in feeding behavior and cell excitability by different transgenic and pharmacological approaches. Goα is involved in the detection of sucrose, glucose, and fructose, but not with trehalose and maltose. Our studies reveal that Goα plays an important role in the perception of some sweet tastants. Because the perception of other sweet stimuli was not affected by mutations in Goα, we also found strong indication for the existence of multiple signaling pathways in the insect gustatory system.
DOI	10.1093/chemse/bjq100
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Chem. Senses
Title	Chemical Senses
Publication Year	1980-
ISBN/ISSN	0379-864X
Data from Reference
Alleles (17)
	Bper\ptxA^Scer\UAS.cKa CG17760^VDRC.cUa CG30054^VDRC.cUa Gαf^GD7540 Gαi^GD12576 Gαo^EP2154 Gαo^GDP.Scer\UAS Gαo^NP3200 Gαo^Scer\UAS.cKa Gαo^VDRC.cUa Gαq^VDRC.cUa Gαs^VDRC.cUa Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Scer\GAL4^{G-oα47A-NP3200} Scer\GAL4^Gr5a.PUn Scer\GAL4^Gr66a.PD Scer\GAL4^hs.PB
Constructs (14)
	P{GAL4-Hsp70.PB} P{GD7540} P{GD12576} P{Gr5a-GAL4.Un} P{Gr66a-GAL4.D} P{UAS(-FRT)G-oα47A.GDP} P{UAS(-FRT)G-oα47A.K} P{UAS(-FRT)ptxA.K} P{UAS-mCD8::GFP.L} P{VDRC.CG17760.U} P{VDRC.CG30054.U} P{VDRC.G-oα47A.U} P{VDRC.G-sα60A.U} P{VDRC.Gα49B.U}
Genes (11)
	Bper\ptxA CG17760 CG30054 Gr5a Gαf Gαi Gαo Gαq Gαs Mmus\Cd8a Scer\GAL4
Insertions (2)
	P{EP}Gαo^EP2154 P{GawB}Gαo^NP3200
Natural transposons (1)
	P-element