Reference Report

Reference
Citation	Ohler, S., Hakeda-Suzuki, S., Suzuki, T. (2011). Hts, the Drosophila homologue of adducin, physically interacts with the transmembrane receptor golden goal to guide photoreceptor axons. Dev. Dyn. 240(1): 135--148. (Export to RIS)
FlyBase ID	FBrf0212583
Publication Type	Research paper
PubMed ID	21128303
PubMed Abstract	Neurons steer their axons towards their proper targets during development. Molecularly, a number of guidance receptors have been identified. The transmembrane protein Golden goal (Gogo) was reported previously to guide photoreceptor (R) axons in the Drosophila visual system. Here, we show that Hts, the Drosophila homologue of Adducin, physically interacts with Gogo's cytoplasmic domain via its head-neck domain. hts null mutants show similar defects in R axon guidance as do gogo mutants. Rescue experiments suggest that the C-terminal tail but not the MARCKS homology domain of Hts is required. Overexpression of either gogo or hts causes abnormally thick swellings of R8 axons in the medulla, but if both are co-overexpressed, R8 axons appear normal and the amount of excessive Hts is reduced. Our results fit with a model where Gogo both positively and negatively regulates Hts that affects the Actin-Spectrin cytoskeleton in growth cone filopodia, thereby guiding R axons.
DOI	10.1002/dvdy.22515
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Dev. Dyn.
Title	Developmental Dynamics
Publication Year	1992-
ISBN/ISSN	1058-8388
Data from Reference
Aberrations (1)
	Df(2R)BSC26
Alleles (13)
	gogo^{GMR.cyto.T:Myr-Src64B,T:Hsap\MYC} gogo^Scer\UAS.T1 hts⁰¹¹⁰³ hts^GMR.Add1 hts^GMR.PD hts^GMR.ShAdd hts^null hts^{Scer\UAS.Add1.T:Hsap\MYC} hts^W532X hts^ΔG Mmus\Cd8a^{Rh6.T:Avic\GFP} Scer\GAL4^GMR.PU β-Spec^G113
Constructs (8)
	P{GMR-GAL4.U} P{GMR-gogo.cyto.myc} P{GMR-hts.Add1} P{GMR-hts.PD} P{GMR-hts.ShAdd} P{Rh6-mCD8-GFP} P{UAS-gogo.T1} P{UAS-hts.Add1.myc}
Genes (7)
	gogo hts Mmus\Cd8a Scer\GAL4 T:Hsap\MYC T:Myr-Src64B β-Spec
Insertions (8)
	P{GMR-gogo.cyto.myc}IIIB P{GMR-hts.Add1}IIIA P{GMR-hts.PD}IIIB P{GMR-hts.ShAdd}IIIB P{PZ}hts⁰¹¹⁰³ P{RS5}hts^5-SZ-4016 P{UAS-hts.Add1.myc}IIIA PBac{WH}hts^f02762
Natural transposons (1)
	P-element