Reference Report

Reference
Citation	Cognigni, P., Bailey, A.P., Miguel-Aliaga, I. (2011). Enteric neurons and systemic signals couple nutritional and reproductive status with intestinal homeostasis. Cell Metab. 13(1): 92--104. (Export to RIS)
FlyBase ID	FBrf0212594
Publication Type	Research paper
PubMed ID	21195352
PubMed Abstract	The gastrointestinal tract is emerging as a key regulator of appetite and metabolism, but daunting neuroanatomical complexity has hampered identification of the relevant signals. Invertebrate models could provide a simple and genetically amenable alternative, but their autonomic nervous system and its visceral functions remain largely unexplored. Here we develop a quantitative method based on defecation behavior to uncover a central role for the Drosophila intestine in the regulation of nutrient intake, fluid, and ion balance. We then identify a key homeostatic role for autonomic neurons and hormones, including a brain-gut circuit of insulin-producing neurons modulating appetite, a vasopressin-like system essential for fluid homeostasis, and enteric neurons mediating sex peptide-induced changes in intestinal physiology. These conserved mechanisms of visceral control, analogous to those found in the enteric nervous system and hypothalamic/pituitary axis, enable the study of autonomic control in a model organism that has proved instrumental in understanding sensory and motor systems.
DOI	10.1016/j.cmet.2010.12.010
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Cell Metab.
Title	Cell Metabolism
Publication Year	2005-
ISBN/ISSN	1550-4131
Data from Reference
Aberrations (2)
	Df(3L)Δ130 Df(3R)Exel8159
Alleles (18)
	Acp70A⁰ Disc\RFP^{Scer\UAS.T:Myr-Src64B} Dscam^{exon17.1.Scer\UAS.T:Avic\GFP} foxo²¹ foxo^W24 Hsap\KCNJ2^{Scer\UAS.T:Avic\GFP-EGFP} Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} ovo^D1 Scer\GAL4^12.1 Scer\GAL4^elav-C155 Scer\GAL4^eve.RN2 Scer\GAL4^Ilp2.215-3 Scer\GAL4^Ilp7.PY Scer\GAL4^Lk.2.2 Scer\GAL4^ppk.1.9 Scer\GAL4^VGlut-OK371 Scer\GAL80^ts.αTub84B TrpA1^Scer\UAS.cKa
Constructs (7)
	P{ppk-GAL4.1.9} P{RN2-GAL4} P{tubP-GAL80^ts} P{UAS-Dscam.exon17.1.GFP} P{UAS-Hsap\KCNJ2.EGFP} P{UAS-mCD8::GFP.L} P{UAS-myr-mRFP}
Genes (18)
	Acp70A brp Disc\RFP Dscam egl eve Fas3 foxo Hsap\KCNJ2 Ilp2 Ilp7 Lk Lkr Mmus\Cd8a ovo Scer\GAL4 Scer\GAL80 TrpA1
Insertions (3)
	P{GAL4}12.1 P{GawB}elav^C155 P{GawB}VGlut^OK371
Transcripts (2)
	Scer\GAL4^eve.RN2RA Scer\GAL4^Ilp2.215-3RA