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Reference Report
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| Citation | Liu, J., Ma, J. (2011). Fates-shifted is an F-box protein that targets Bicoid for degradation and regulates developmental fate determination in Drosophila embryos. Nat. Cell Biol. 13(1): 22--29. (Export to RIS) | ||
| FlyBase ID | FBrf0212612 | ||
| Publication Type | Research paper | ||
| PubMed ID | 21170036 | ||
| PubMed Abstract | Bicoid (Bcd) is a morphogenetic protein that instructs patterning along the anterior-posterior (A-P) axis in Drosophila melanogaster embryos. Despite extensive studies, what controls the formation of a normal concentration gradient of Bcd remains an unresolved and controversial question. Here, we show that Bcd protein degradation is mediated by the ubiquitin-proteasome pathway. We have identified an F-box protein, encoded by fates-shifted (fsd), that has an important role in Bcd protein degradation by targeting it for ubiquitylation. Embryos from females lacking fsd have an altered Bcd gradient profile, resulting in a shift of the fatemap along the A-P axis. Our study is an experimental demonstration that, contrary to an alternative hypothesis, Bcd protein degradation is required for normal gradient formation and developmental fate determination. | ||
| DOI | 10.1038/ncb2141 | ||
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| Language of Publication | English | ||
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| Publication Type | Journal | ||
| Abbreviation | Nat. Cell Biol. | ||
| Title | Nature Cell Biology | ||
| Publication Year | 1999- | ||
| ISBN/ISSN | 1465-7392 1476-4679 | ||
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Data from Reference
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| Alleles (2)
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| Constructs (1)
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| Genes (6)
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| Insertions (1)
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