Reference Report

Reference
Citation	Ding, Z.Y., Wang, Y.H., Luo, Z.K., Lee, H.F., Hwang, J., Chien, C.T., Huang, M.L. (2011). Glial cell adhesive molecule unzipped mediates axon guidance in Drosophila. Dev. Dyn. 240(1): 122--134. (Export to RIS)
FlyBase ID	FBrf0212620
Publication Type	Research paper
PubMed ID	21117153
PubMed Abstract	Axon guidance needs help from the glial cell system during embryogenesis. In the Drosophila embryonic central nervous system (CNS), longitudinal glia (LG) have been implicated in axon guidance but the mechanism remains unclear. We identified the protein encoded by the Drosophila gene unzipped (uzip) as a novel cell adhesion molecule (CAM). Uzip expressed in Drosophila S2 cells triggered cell aggregation through homophilic binding. In the embryonic CNS, Uzip was mainly produced by the LG but was also located at axons, which is consistent with the secretion of Uzip expressed in cultured cells. Although uzip mutants displayed no axonal defect, loss of uzip enhanced the axonal defects in the mutant of N-cadherin (CadN) and the Wnt gene family member wnt5. Overexpression of uzip could rescue the phenotype in the CadNuzip(D43) mutant. Thus, Uzip is a novel CAM from the LG regulating axon guidance.
DOI	10.1002/dvdy.22508
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Dev. Dyn.
Title	Developmental Dynamics
Publication Year	1992-
ISBN/ISSN	1058-8388
Data from Reference
Aberrations (1)
	Df(2R)BSC608
Alleles (18)
	Btau\MAPT^{Sema-2b.T:Hsap\MYC} CadN^M19 Ecol\lacZ^loco-rC56 gcm^N7-4 Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Scer\GAL4^elav-C155 Scer\GAL4^repo Scer\GAL4^sim.PS T:Avic\GFP^CFP uzip²³ uzip^D43 uzip^{dsRNA.Sym.Scer\UAS} uzip^EP-C04101 uzip^f01534 uzip^f02444 uzip^{Scer\UAS.T:Avic\GFP-CFP} Wnt5⁴⁰⁰ Wnt5^Scer\UAS.cFa
Constructs (7)
	P{EP} P{GAL4-sim.S} P{Sema-2b-tau-myc} P{Sym-UAS-uzip} P{UAS-mCD8::GFP.L} P{UAS-uzip-CFP} P{UAS-Wnt5.F}
Genes (10)
	Btau\MAPT CadN Ecol\lacZ Fas2 gcm Mmus\Cd8a Scer\GAL4 Sema-2b uzip Wnt5
Insertions (6)
	P{EP}uzip^C04101 P{GAL4}repo P{GawB}elav^C155 P{lacZ-un1}loco^rC56 PBac{WH}uzip^f01534 PBac{WH}uzip^f02444
Natural transposons (1)
	P-element