Reference Report

Reference
Citation	Chen, S., Zhang, Y.E., Long, M. (2010). New genes in Drosophila quickly become essential. Science 330(6011): 1682--1685. (Export to RIS)
FlyBase ID	FBrf0212650
Publication Type	Research paper
PubMed ID	21164016
PubMed Abstract	To investigate the origin and evolution of essential genes, we identified and phenotyped 195 young protein-coding genes, which originated 3 to 35 million years ago in Drosophila. Knocking down expression with RNA interference showed that 30% of newly arisen genes are essential for viability. The proportion of genes that are essential is similar in every evolutionary age group that we examined. Under constitutive silencing of these young essential genes, lethality was high in the pupal stage and also found in the larval stages. Lethality was attributed to diverse cellular and developmental defects, such as organ formation and patterning defects. These data suggest that new genes frequently and rapidly evolve essential functions and participate in development.
DOI	10.1126/science.1196380
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Supplementary material	Supporting Online Material. [FBrf0216693]
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Science
Title	Science
Publication Year	1895-
ISBN/ISSN	0036-8075
Data from Reference
Alleles (23)
	CG13463^GD6119 CG13463^KK103918 CG31406^GD14631 CG31406^GD15569 CG31406^GD16282 CG31406^KK113316 CG32301^GD3573 CG32301^GD16147 CG33459^GD16003 CG33459^KK104673 Cyp9f2^GD5631 Cyp9f2^KK108846 Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} RpS28a^GD13125 RpS28a^GD15792 RpS28a^KK112278 Scer\GAL4^Act5C.PU Scer\GAL4^bbg-C96 Scer\GAL4^Bx-MS1096 Scer\GAL4^pnr-MD237 Spn77Bc^KK113240 Sr-CIII^GD5098 Sr-CIII^KK112258
Constructs (20)
	P{Act5C-GAL4.U} P{GD3573} P{GD5098} P{GD5631} P{GD6119} P{GD13125} P{GD14631} P{GD15569} P{GD15792} P{GD16003} P{GD16147} P{GD16282} P{KK103918} P{KK104673} P{KK108846} P{KK112258} P{KK112278} P{KK113240} P{KK113316} P{UAS-mCD8::GFP.L}
Genes (20)
	CG3397 CG8358 CG12224 CG13463 CG30395 CG31406 CG32301 CG33459 CR12842 Cyp9f2 HP6 Mmus\Cd8a p24-2 Ref1 Ref2 RpS28a Scer\GAL4 Spn28F Spn77Bc Sr-CIII
Insertions (3)
	P{GawB}bbg^C96 P{GawB}Bx^MS1096 P{GawB}pnr^MD237