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Citation
Jiang, H., Grenley, M.O., Bravo, M.J., Blumhagen, R.Z., Edgar, B.A. (2011). EGFR/Ras/MAPK Signaling Mediates Adult Midgut Epithelial Homeostasis and Regeneration in Drosophila.  Cell Stem Cell 8(1): 84--95.
FlyBase ID
FBrf0212694
Publication Type
Research paper
Abstract

Many tissues in higher animals undergo dynamic homeostatic growth, wherein damaged or aged cells are replaced by the progeny of resident stem cells. To maintain homeostasis, stem cells must respond to tissue needs. Here we show that in response to damage or stress in the intestinal (midgut) epithelium of adult Drosophila, multiple EGFR ligands and rhomboids (intramembrane proteases that activate some EGFR ligands) are induced, leading to the activation of EGFR signaling in intestinal stem cells (ISCs). Activation of EGFR signaling promotes ISC division and midgut epithelium regeneration, thereby maintaining tissue homeostasis. ISCs defective in EGFR signaling cannot grow or divide, are poorly maintained, and cannot support midgut epithelium regeneration after enteric infection by the bacterium Pseudomonas entomophila. Furthermore, ISC proliferation induced by Jak/Stat signaling is dependent upon EGFR signaling. Thus the EGFR/Ras/MAPK signaling pathway plays central, essential roles in ISC maintenance and the feedback system that mediates intestinal homeostasis.

Graphical Abstract
Obtained with permission from Cell Press.
PubMed ID
PubMed Central ID
PMC3021119 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell Stem Cell
    Title
    Cell Stem Cell
    Publication Year
    2007--
    ISBN/ISSN
    1934-5909 1875-9777
    Data From Reference
    Aberrations (1)
    Alleles (43)
    Genes (36)
    Sequence Features (1)
    Natural transposons (1)
    Insertions (8)
    Experimental Tools (2)
    Transgenic Constructs (29)
    Transcripts (3)