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| Citation | Yarali, A., Gerber, B. (2010). A Neurogenetic Dissociation between Punishment-, Reward-, and Relief-Learning in Drosophila. Front. Behav. Neurosci. 4(): 189. (Export to RIS) | ||
| FlyBase ID | FBrf0212711 | ||
| Publication Type | Research paper | ||
| PubMed ID | 21206762 | ||
| PubMed Abstract | What is particularly worth remembering about a traumatic experience is what brought it about, and what made it cease. For example, fruit flies avoid an odor which during training had preceded electric shock punishment; on the other hand, if the odor had followed shock during training, it is later on approached as a signal for the relieving end of shock. We provide a neurogenetic analysis of such relief learning. Blocking, using UAS-shibire(ts1), the output from a particular set of dopaminergic neurons defined by the TH-Gal4 driver partially impaired punishment learning, but left relief learning intact. Thus, with respect to these particular neurons, relief learning differs from punishment learning. Targeting another set of dopaminergic/serotonergic neurons defined by the DDC-Gal4 driver on the other hand affected neither punishment nor relief learning. As for the octopaminergic system, the tbh(M18) mutation, compromising octopamine biosynthesis, partially impaired sugar-reward learning, but not relief learning. Thus, with respect to this particular mutation, relief learning, and reward learning are dissociated. Finally, blocking output from the set of octopaminergic/tyraminergic neurons defined by the TDC2-Gal4 driver affected neither reward, nor relief learning. We conclude that regarding the used genetic tools, relief learning is neurogenetically dissociated from both punishment and reward learning. This may be a message relevant also for analyses of relief learning in other experimental systems including man. | ||
| DOI | 10.3389/fnbeh.2010.00189 | ||
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| Language of Publication | English | ||
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| Publication Type | Journal | ||
| Abbreviation | Front. Behav. Neurosci. | ||
| Title | Frontiers in behavioral neuroscience | ||
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| ISBN/ISSN | 1662-5153 | ||
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Data from Reference
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| Constructs (5)
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| Genes (4)
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| Natural transposons (1)
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