|Citation||Yarali, A., Gerber, B. (2010). A Neurogenetic Dissociation between Punishment-, Reward-, and Relief-Learning in Drosophila. Front. Behav. Neurosci. 4(): 189. (Export to RIS)|
|Publication Type||Research paper|
|PubMed Abstract||What is particularly worth remembering about a traumatic experience is what brought it about, and what made it cease. For example, fruit flies avoid an odor which during training had preceded electric shock punishment; on the other hand, if the odor had followed shock during training, it is later on approached as a signal for the relieving end of shock. We provide a neurogenetic analysis of such relief learning. Blocking, using UAS-shibire(ts1), the output from a particular set of dopaminergic neurons defined by the TH-Gal4 driver partially impaired punishment learning, but left relief learning intact. Thus, with respect to these particular neurons, relief learning differs from punishment learning. Targeting another set of dopaminergic/serotonergic neurons defined by the DDC-Gal4 driver on the other hand affected neither punishment nor relief learning. As for the octopaminergic system, the tbh(M18) mutation, compromising octopamine biosynthesis, partially impaired sugar-reward learning, but not relief learning. Thus, with respect to this particular mutation, relief learning, and reward learning are dissociated. Finally, blocking output from the set of octopaminergic/tyraminergic neurons defined by the TDC2-Gal4 driver affected neither reward, nor relief learning. We conclude that regarding the used genetic tools, relief learning is neurogenetically dissociated from both punishment and reward learning. This may be a message relevant also for analyses of relief learning in other experimental systems including man.|
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|Language of Publication||English|
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|Also Published As|
|Abbreviation||Front. Behav. Neurosci.|
|Title||Frontiers in behavioral neuroscience|
|Data from Reference|
|Natural transposons (1)|