Reference Report

Reference
Citation	Oh, H., Irvine, K.D. (2011). Cooperative Regulation of Growth by Yorkie and Mad through bantam. Dev. Cell 20(1): 109--122. (Export to RIS)
FlyBase ID	FBrf0212763
Publication Type	Research paper
PubMed ID	21238929
PubMed Abstract	The Dpp and Fat-Hippo signaling pathways both regulate growth in Drosophila. Dpp is a BMP family ligand and acts via a Smad family DNA-binding transcription factor, Mad. Fat-Hippo signaling acts via a non-DNA-binding transcriptional coactivator protein, Yorkie. Here, we show that these pathways are directly interlinked. They act synergistically to promote growth, in part via regulation of the microRNA gene bantam, and their ability to promote growth is mutually dependent. Yorkie and Mad physically bind each other, and we identify a 410 bp minimal enhancer of bantam that responds to Yorkie:Mad in vivo and in cultured cells, and show that both Yorkie and Mad associate with this enhancer in vivo. Our results indicate that in promoting the growth of Drosophila tissues, Fat-Hippo and Dpp signaling contribute distinct subunits of a shared transcriptional activation complex, Yorkie:Mad.
DOI	10.1016/j.devcel.2010.12.002
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Dev. Cell
Title	Developmental Cell
Publication Year	2001-
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Data from Reference
Alleles (27)
	Avic\GFP^{EGFP.ban.αTub84B} Avic\GFP^{th.3.5.T:nls-tra} BacA\p35^Scer\UAS.cHa ban^GS brk^KK110138 brk^Scer\UAS.cJa Dcr-2^Scer\UAS.cDa Ecol\lacZ^ban.br2.5 Ecol\lacZ^{ban.br2.5Δ1-Δ2} Ecol\lacZ^ban.brC12 Ecol\lacZ^bi-X35 Ecol\lacZ^Dad-j1E4 Ecol\lacZ^th-j5C8 Mad¹⁰ Mad¹² Mad^GD4121 Mad^{Scer\UAS.T:Zzzz\FLAG} Scer\GAL4^en-e16E Scer\GAL4^GMR.PF Scer\GAL4^{Scer\FRT.Act5C} tkv^{Q253D.Scer\UAS.cNc} yki^B5 yki^KK109756 yki^{S111A.S250A.Scer\UAS.T:SV5\V5} yki^{S168A.Scer\UAS.T:SV5\V5} yki^{S250A.Scer\UAS.T:SV5\V5} yki^{Scer\UAS.cOa.T:SV5\V5}
Constructs (19)
	P{AyGAL4} P{ban-lacZ.br2.5} P{ban-lacZ.br2.5Δ1-Δ2} P{ban-lacZ.brC12} P{GAL4-ninaE.GMR} P{GD4121} P{KK109756} P{KK110138} P{th-GFP.3.5} P{Tub-EGFP.ban} P{UAS(-FRT)tkv.Q253D.Nc} P{UAS-brk.J} P{UAS-Dcr-2.D} P{UAS-Mad.FLAG} P{UAS-p35.H} P{UAS-yki.S111A.S250A.V5} P{UAS-yki.S168A.V5} P{UAS-yki.S250A.V5} P{UAS-yki.V5.O}
Genes (17)
	Avic\GFP BacA\p35 ban bi brk Dad Dcr-2 Ecol\lacZ Mad Med salr Scer\GAL4 sd T:Zzzz\FLAG tkv vg yki
Insertions (5)
	P{en2.4-GAL4}e16E P{GSV1}ban^GS P{lacW}bi^X35 P{lacW}Dad^j1E4 P{lacW}th^j5C8
Natural transposons (1)
	P-element
Sequence features (4)
	ban_br-1.2 ban_br-5.5 ban_br-6.6 ban_br-C12