Reference Report

Reference
Citation	Ellis, L.L., Carney, G.E. (2011). Socially-Responsive Gene Expression in Male Drosophila melanogaster Is Influenced by the Sex of the Interacting Partner. Genetics 187(1): 157--169. (Export to RIS)
FlyBase ID	FBrf0212780
Publication Type	Research paper
PubMed ID	20980240
PubMed Abstract	Behavior is influenced by an organism's genes and environment, including its interactions with same or opposite sex individuals. Drosophila melanogaster perform innate, yet socially modifiable, courtship behaviors that are sex specific and require rapid integration and response to multiple sensory cues. Furthermore, males must recognize and distinguish other males from female courtship objects. It is likely that perception, integration, and response to sex-specific cues is partially mediated by changes in gene expression. Reasoning that social interactions with members of either sex would impact gene expression, we compared expression profiles in heads of males that courted females, males that interacted with other males, or males that did not interact with another fly. Expression of 281 loci changes when males interact with females, whereas 505 changes occur in response to male-male interactions. Of these genes, 265 are responsive to encounters with either sex and 240 respond specifically to male-male interactions. Interestingly, 16 genes change expression only when a male courts a female, suggesting that these changes are a specific response to male-female courtship interactions. We supported our hypothesis that socially-responsive genes can function in behavior by showing that egghead (egh) expression, which increases during social interactions, is required for robust male-to-female courtship. We predict that analyzing additional socially-responsive genes will give us insight into genes and neural signaling pathways that influence reproductive and other behavioral interactions.
DOI	10.1534/genetics.110.122754
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Genetics
Title	Genetics
Publication Year	1916-
ISBN/ISSN	0016-6731
Data from Reference
Alleles (8)
	egh^+tP2 egh^EP804 egh^EY03917 egh^GD3206 egh^{Scer\UAS.T:Ivir\HA1} Scer\GAL4^ap-md544 Scer\GAL4^elav-C155 Scer\GAL80^ts.αTub84B
Constructs (4)
	P{egh.P2} P{GD3206} P{tubP-GAL80^ts} P{UAS-egh.HA}
Genes (49)
	Ance-5 Atg14 B52 bru-3 cac CG1416 CG2217 CG4269 CG4629 CG4962 CG9266 CG9377 CG10077 CG10621 CG13116 CG14210 CG14688 CG18477 CG31181 CG31182 CG42370 CG42492 Cks30A cwo Cyp28d2 Dr Drsl5 E(spl)mβ-HLH egh fit Gfat1 Ggt-1 h Hrb98DE Lsp2 mbl mod(mdg4) olf186-M pdm3 ps Rim Scer\GAL4 Scer\GAL80 Sh Spn88Ea stj sug Tdc1 twin
Insertions (2)
	P{GawB}ap^md544 P{GawB}elav^C155
Natural transposons (1)
	P-element