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Citation
Weiss, L.A., Dahanukar, A., Kwon, J.Y., Banerjee, D., Carlson, J.R. (2011). The Molecular and Cellular Basis of Bitter Taste in Drosophila.  Neuron 69(2): 258--272.
FlyBase ID
FBrf0212834
Publication Type
Research paper
Abstract

The extent of diversity among bitter-sensing neurons is a fundamental issue in the field of taste. Data are limited and conflicting as to whether bitter neurons are broadly tuned and uniform, resulting in indiscriminate avoidance of bitter stimuli, or diverse, allowing a more discerning evaluation of food sources. We provide a systematic analysis of how bitter taste is encoded by the major taste organ of the Drosophila head, the labellum. Each of 16 bitter compounds is tested physiologically against all 31 taste hairs, revealing responses that are diverse in magnitude and dynamics. Four functional classes of bitter neurons are defined. Four corresponding classes are defined through expression analysis of all 68 gustatory taste receptors. A receptor-to-neuron-to-tastant map is constructed. Misexpression of one receptor confers bitter responses as predicted by the map. These results reveal a degree of complexity that greatly expands the capacity of the system to encode bitter taste.

PubMed ID
PubMed Central ID
PMC3033050 (PMC) (EuropePMC)
Related Publication(s)
Supplementary material
Personal communication to FlyBase

Nomenclature correspondence table for adult taste sensilla.
Weiss, 2013.2.7, Nomenclature correspondence table for adult taste sensilla. [FBrf0220802]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Neuron
    Title
    Neuron
    Publication Year
    1988-
    ISBN/ISSN
    0896-6273
    Data From Reference
    Alleles (48)
    Genes (43)
    Experimental Tools (1)
    Transgenic Constructs (47)
    Transcripts (40)