Reference Report

Reference
Citation	Gibert, J.M., Karch, F., Schlötterer, C. (2011). Segregating Variation in the Polycomb Group Gene cramped Alters the Effect of Temperature on Multiple Traits. PLoS Genet. 7(1): e1001280. (Export to RIS)
FlyBase ID	FBrf0212864
Publication Type	Research paper
PubMed ID	21283785
PubMed Abstract	The phenotype produced by a given genotype can be strongly modulated by environmental conditions. Therefore, natural populations continuously adapt to environment heterogeneity to maintain optimal phenotypes. It generates a high genetic variation in environment-sensitive gene networks, which is thought to facilitate evolution. Here we analyze the chromatin regulator crm, identified as a candidate for adaptation of Drosophila melanogaster to northern latitudes. We show that crm contributes to environmental canalization. In particular, crm modulates the effect of temperature on a genomic region encoding Hedgehog and Wingless signaling effectors. crm affects this region through both constitutive heterochromatin and Polycomb silencing. Furthermore, we show that crm European and African natural variants shift the reaction norms of plastic traits. Interestingly, traits modulated by crm natural variants can differ markedly between Drosophila species, suggesting that temperature adaptation facilitates their evolution.
DOI	10.1371/journal.pgen.1001280
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Language of Publication	English
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Publication Type	Journal
Abbreviation	PLoS Genet.
Title	PLoS Genetics
Publication Year	2005-
ISBN/ISSN	1553-7404 1553-7390
Data from Reference
Aberrations (1)
	Df(4)ED6364
Alleles (23)
	Asx^XF23 bab1^Ar07 ci^D crm³² crm^AM crm^AT crm^{Del-I.Scer\UAS.T:Avic\GFP-YFP.Venus} crm^{Del-II.Scer\UAS.T:Avic\GFP-YFP.Venus} crm^{Del-III.Scer\UAS.T:Avic\GFP-YFP.Venus} crm^{Del-IV.Scer\UAS.T:Avic\GFP-YFP.Venus} crm^{Del-V.Scer\UAS.T:Avic\GFP-YFP.Venus} crm^{Del-VI.Scer\UAS.T:Avic\GFP-YFP.Venus} crm^{Del-VII.Scer\UAS.T:Avic\GFP-YFP.Venus} crm^GM crm^GT Ecol\lacZ^ci-Dplac Pcl¹¹ ph-p⁶⁰² Scer\GAL4^bi-omb-Gal4 Scer\GAL4^da.G32 Scer\GAL4^pnr-MD237 Su(var)3-9¹⁷ T:Avic\GFP^YFP.Venus
Constructs (12)
	P{crm.AM} P{crm.AT} P{crm.GM} P{crm.GT} P{GAL4-da.G32} P{UAS-crm.Del-I.Venus} P{UAS-crm.Del-II.Venus} P{UAS-crm.Del-III.Venus} P{UAS-crm.Del-IV.Venus} P{UAS-crm.Del-V.Venus} P{UAS-crm.Del-VI.Venus} P{UAS-crm.Del-VII.Venus}
Genes (12)
	Asx bab1 bab2 ci crm Ecol\lacZ pan Pcl ph-d ph-p Scer\GAL4 Su(var)3-9
Insertions (3)
	P{GAL4}bi^omb-Gal4 P{GawB}pnr^MD237 P{lacW}ci^Dplac
Natural transposons (1)
	P-element