Reference Report

Reference
Citation	Szuperák, M., Salah, S., Meyer, E.J., Nagarajan, U., Ikmi, A., Gibson, M.C. (2011). Feedback regulation of Drosophila BMP signaling by the novel extracellular protein Larval Translucida. Development 138(4): 715--724. (Export to RIS)
FlyBase ID	FBrf0212881
Publication Type	Research paper
PubMed ID	21266407
PubMed Abstract	The cellular response to the Drosophila BMP 2/4-like ligand Decapentaplegic (DPP) serves as one of the best-studied models for understanding the long-range control of tissue growth and pattern formation during animal development. Nevertheless, fundamental questions remain unanswered regarding extracellular regulation of the ligand itself, as well as the nature of the downstream transcriptional response to BMP pathway activation. Here, we report the identification of larval translucida (ltl), a novel target of BMP activity in Drosophila. Both gain- and loss-of-function analyses implicate LTL, a leucine-rich repeat protein, in the regulation of wing growth and vein patterning. At the molecular level, we demonstrate that LTL is a secreted protein that antagonizes BMP-dependent MAD phosphorylation, indicating that it regulates DPP/BMP signaling at or above the level of ligand-receptor interactions. Furthermore, based on genetic interactions with the DPP-binding protein Crossveinless 2 and biochemical interactions with the glypican Dally-like, we propose that LTL acts in the extracellular space where it completes a novel auto-regulatory loop that modulates BMP activity.
DOI	10.1242/dev.059477
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Secondary IDs
Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (1)
	Df(3L)D26
Alleles (20)
	cv-2¹ cv-2^Scer\UAS.cBa dlp^{Scer\UAS.T:Ivir\HA1} dpp^Scer\UAS.cSa ltl¹ ltl² ltl³ ltl⁴ ltl^{C.Scer\UAS.T:Avic\GFP} ltl^{N.Scer\UAS.T:Avic\GFP} ltl^N ltl^Scer\UAS.cSa ltl^{Scer\UAS.T:Ivir\HA1,T:Zzzz\FLAG} Scer\GAL4^A9 Scer\GAL4^en-e16E Scer\GAL4^hh-Gal4 Scer\GAL4^unspecified tkv^{Q253D.Scer\UAS.cNb} tkv^xtr w^+mC
Constructs (8)
	P{UAS-cv-2.B} P{UAS-dlp.HA} P{UAS-dpp.S} P{UAS-ltl.HA-2XFLAG} P{UAS-ltl.S} P{UAS-ltl-gfp-C} P{UAS-N-gfp-ltl} P{UAS-tkv.Q253D.Nb}
Genes (18)
	bi cv-2 Dad dlp Doc1 Doc2 Doc3 dpp ltl Mad magu salm Scer\GAL4 T:Avic\GFP T:Ivir\HA1 T:Zzzz\FLAG tkv w
Insertions (6)
	P{en2.4-GAL4}e16E P{GAL4}A9 P{GAL4}hh^Gal4 P{UAS-ltl.S}1 P{UAS-ltl.S}5 PBac{WH}f03786
Natural transposons (1)
	P-element