Reference Report

Reference
Citation	Grusche, F.A., Degoutin, J.L., Richardson, H.E., Harvey, K.F. (2011). The Salvador/Warts/Hippo pathway controls regenerative tissue growth in Drosophila melanogaster. Dev. Biol. 350(2): 255--266. (Export to RIS)
FlyBase ID	FBrf0212888
Publication Type	Research paper
PubMed ID	21111727
PubMed Abstract	During tissue regeneration, cell proliferation replaces missing structures to restore organ function. Regenerative potential differs greatly between organs and organisms; for example some amphibians can regrow entire limbs whereas mammals cannot. The process of regeneration relies on several signaling pathways that control developmental tissue growth, and implies the existence of organ size-control checkpoints that regulate both developmental, and regenerative, growth. Here we explore the role of one such checkpoint, the Salvador-Warts-Hippo pathway, in tissue regeneration. The Salvador-Warts-Hippo pathway limits tissue growth by repressing the Yorkie transcriptional co-activator. Several proteins serve as upstream modulators of this pathway including the atypical cadherins, Dachsous and Fat, whilst the atypical myosin, Dachs, functions downstream of Fat to activate Yorkie. Using Drosophila melanogaster imaginal discs we show that Salvador-Warts-Hippo pathway activity is repressed in regenerating tissue and that Yorkie is rate-limiting for regeneration of the developing wing. We show that regeneration is compromised in dachs mutant wing discs, but that proteins in addition to Fat and Dachs are likely to modulate Yorkie activity in regenerating cells. In conclusion our data reveal the importance of Yorkie hyperactivation for tissue regeneration and suggest that multiple upstream inputs, including Fat-Dachsous signaling, sense tissue damage and regulate Yorkie activity during regeneration of epithelial tissues.
DOI	10.1016/j.ydbio.2010.11.020
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Dev. Biol.
Title	Developmental Biology
Publication Year	1959-
ISBN/ISSN	0012-1606
Data from Reference
Alleles (20)
	d¹ d^GC13 debcl^{Scer\UAS.T:Ivir\HA1} Ecol\lacZ^ex-697 Ecol\lacZ^th-j5C8 egr^Scer\UAS.cMa ex⁶⁹⁷ ex^e1 ex^MGH1 ft⁸ hyd^K3.5 lin^P14A rpr^Scer\UAS.C Scer\GAL4^en-e16E Scer\GAL4^rn-GAL4-5 scrib¹ TSG101² Vps25^Pb2931 wts^{Scer\UAS.T:Hsap\MYC} yki^B5
Constructs (4)
	P{UAS-debcl.HA} P{UAS-eiger.M} P{UAS-rpr.C} P{UAS-wts.MYC}
Genes (15)
	d debcl Ecol\lacZ egr ex ft hyd lin rpr Scer\GAL4 scrib TSG101 Vps25 wts yki
Insertions (4)
	P{en2.4-GAL4}e16E P{GawB}rn^GAL4-5 P{lacW}ex⁶⁹⁷ P{lacW}th^j5C8