Reference Report

Reference
Citation	Lieber, T., Kidd, S., Struhl, G. (2011). DSL-Notch Signaling in the Drosophila Brain in Response to Olfactory Stimulation. Neuron 69(3): 468--481. (Export to RIS)
FlyBase ID	FBrf0212999
Publication Type	Research paper
PubMed ID	21315258
PubMed Abstract	Delta/Serrate/Lag2 (DSL) ligands and their Notch family receptors have profound and pervasive roles in development. They are also expressed in adult tissues, notably in mature neurons and glia in the brain, where their roles are unknown. Here, focusing on the sense of smell in adult Drosophila, we show that Notch is activated in select olfactory receptor neurons (ORNs) in an odorant-specific fashion. This response requires olfactory receptor activity and the Notch ligand Delta. We present evidence that Notch activation depends on synaptic transmission by the ORNs in which the receptors are active and is modulated by the activity of local interneurons in the antennal lobe. It is also subject to regulatory inputs from olfactory receptor activity in other ORNs. These findings identify a correlate of stimulus-dependent brain activity and potentially new forms of neural integration and plasticity.
DOI	10.1016/j.neuron.2010.12.015
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Neuron
Title	Neuron
Publication Year	1988-
ISBN/ISSN	0896-6273
Data from Reference
Alleles (20)
	Avic\GFP^{d.Ecol\lexAop.T:SV40\nls2} Avic\GFP^{d.Scer\UAS.T:SV40\nls2} Ctet\TeTxLC^{IMPTNT-Q.Scer\UAS} Ctet\TeTxLC^TNT.Scer\UAS Disc\RFP^{Gr21a.DsRedT4.T:nls-tra} Disc\RFP^{hs.DsRedT4.T:nls-tra} Disc\RFP^{Or82a.DsRedT4.T:nls-tra} Dl^6B Dl^RF N^{3.hs.T:Scer\GAL4,T:Hsim\VP16} N^{3.αTub84B.T:Ecol\lexA,T:Hsim\VP16} N^{3.αTub84B.T:Scer\GAL4,T:Hsim\VP16} Or43b¹ Or82a^{Or43b.T:nls-tra} Scer\GAL4^{exba-krasavietz} Scer\GAL4^Gr21a.9.323 Scer\GAL4^NP1227 Scer\GAL4^Or82a.PF Scer\GAL4^Sxl-NP2426 Scer\GAL80^ts.αTub84B
Constructs (12)
	P{Gr21a-GAL4.9.323} P{Gr21a-RFP.dsRed.nls} P{LexAop-dGFP.nls} P{Or43b-Or82a.nls} P{Or82a-GAL4.F} P{Or82a-RFP.dsRed.nls} P{tub-N⁺.LV.3} P{tub-N⁺-GV.3} P{tubP-GAL80^ts} P{UAS-dGFP.nls} P{UAS-TeTxLC.(-)Q} P{UAS-TeTxLC.tnt}
Genes (16)
	Avic\GFP brp Ctet\TeTxLC Disc\RFP Dl elav N Or43b Or82a Psn Scer\GAL4 Scer\GAL80 T:Ecol\lexA T:Hsim\VP16 T:nls-tra T:Scer\GAL4
Insertions (3)
	P{GAL4}exba^krasavietz P{GawB}LN1^NP1227 P{GawB}Sxl^NP2426
Natural transposons (1)
	P-element