Reference Report

Reference
Citation	Müller, M., Pym, E.C., Tong, A., Davis, G.W. (2011). Rab3-GAP Controls the Progression of Synaptic Homeostasis at a Late Stage of Vesicle Release. Neuron 69(4): 749--762. (Export to RIS)
FlyBase ID	FBrf0213055
Publication Type	Research paper
PubMed ID	21338884
PubMed Abstract	Homeostatic signaling systems stabilize neural function through the modulation of neurotransmitter receptor abundance, ion channel density, and presynaptic neurotransmitter release. Molecular mechanisms that drive these changes are being unveiled. In theory, molecular mechanisms may also exist to oppose the induction or expression of homeostatic plasticity, but these mechanisms have yet to be explored. In an ongoing electrophysiology-based genetic screen, we have tested 162 new mutations for genes involved in homeostatic signaling at the Drosophila NMJ. This screen identified a mutation in the rab3-GAP gene. We show that Rab3-GAP is necessary for the induction and expression of synaptic homeostasis. We then provide evidence that Rab3-GAP relieves an opposing influence on homeostasis that is catalyzed by Rab3 and which is independent of any change in NMJ anatomy. These data define roles for Rab3-GAP and Rab3 in synaptic homeostasis and uncover a mechanism, acting at a late stage of vesicle release, that opposes the progression of homeostatic plasticity.
DOI	10.1016/j.neuron.2011.01.025
Related Publication(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Neuron
Title	Neuron
Publication Year	1988-
ISBN/ISSN	0896-6273
Data from Reference
Aberrations (1)
	Df(2L)ED775
Alleles (7)
	GluRIIA^SP16 Rab3^{Q80L.Scer\UAS.P\T.T:Avic\GFP-YFP} Rab3^rup Rab3-GAP^c04953 Rab3-GAP^{Scer\UAS.T:Avic\GFP-YFP.Venus} Scer\GAL4^elav-C155 T:Avic\GFP^YFP.Venus
Constructs (2)
	P{UASp-YFP.Rab3.Q80L} P{UAS-YFP-Rab3-GAP}
Genes (7)
	brp dlg1 GluRIIA Rab3 Rab3-GAP Scer\GAL4 Syt1
Insertions (2)
	P{GawB}elav^C155 PBac{PB}Rab3-GAP^c04953
Natural transposons (1)
	P-element