Reference Report

Reference
Citation	Gallio, M., Ofstad, T.A., Macpherson, L.J., Wang, J.W., Zuker, C.S. (2011). The coding of temperature in the Drosophila brain. Cell 144(4): 614--624. (Export to RIS)
FlyBase ID	FBrf0213085
Publication Type	Research paper
PubMed ID	21335241
PubMed Abstract	Thermosensation is an indispensable sensory modality. Here, we study temperature coding in Drosophila, and show that temperature is represented by a spatial map of activity in the brain. First, we identify TRP channels that function in the fly antenna to mediate the detection of cold stimuli. Next, we identify the hot-sensing neurons and show that hot and cold antennal receptors project onto distinct, but adjacent glomeruli in the Proximal-Antennal-Protocerebrum (PAP) forming a thermotopic map in the brain. We use two-photon imaging to reveal the functional segregation of hot and cold responses in the PAP, and show that silencing the hot- or cold-sensing neurons produces animals with distinct and discrete deficits in their behavioral responses to thermal stimuli. Together, these results demonstrate that dedicated populations of cells orchestrate behavioral responses to different temperature stimuli, and reveal a labeled-line logic for the coding of temperature information in the brain.
DOI	10.1016/j.cell.2011.01.028
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Aberrations (2)
	Df(3L)Exel6131 Df(3L)Exel9007
Alleles (15)
	Avic\GFP^{GCaMP1.3.Scer\UAS.cAa} Avic\GFP^{Scer\UAS.T:SV40\nls2} brv1^L563STOP brv1^NP4486 brv2^+t4 brv2^W205STOP brv3^{dsRNA.Scer\UAS} Ctet\TeTxLC^TNT.Scer\UAS Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Scer\FLP1^ey.PN Scer\GAL4^brv1-NP4486 Scer\GAL4^elav.PU Scer\GAL4^hot-cell Scer\GAL4^scrt-11-6 Scer\GAL80^αTub84B.PC
Constructs (10)
	P{brv2.4} P{elav-GAL4.U} P{ey-FLP.N} P{GawB} P{UAS-brv3.RNAi} P{UAS-GCaMP1.3.A} P{UAS-GFP.nls} P{UAS-mCD8::GFP.L} P{UAS-TeTxLC.tnt} P{αTub84B(FRT.Gal80.y⁺)GAL4.C}
Genes (10)
	Avic\GFP brv1 brv2 brv3 Ctet\TeTxLC Mmus\Cd8a Scer\FLP1 Scer\GAL4 Scer\GAL80 TrpA1
Insertions (3)
	P{GawB}hot-cell P{GawB}NP4486 P{GawB}scrt^11-6
Natural transposons (1)
	P-element
Transcripts (2)
	Scer\GAL4^brv1-NP4486RA Scer\GAL4^hot-cellRA