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Hadjieconomou, D., Timofeev, K., Salecker, I. (2011). A step-by-step guide to visual circuit assembly in Drosophila.  Curr. Opin. Neurobiol. 21(1): 76--84.
FlyBase ID
FBrf0213187
Publication Type
Review
Abstract

The ability of vertebrates and insects to perceive and process information about the visual world is mediated by neural circuits, which share a strikingly conserved architecture of reiterated columnar and layered synaptic units. Recent genetic approaches conferring single-cell resolution have enabled major advances in our understanding of the cellular and molecular strategies that orchestrate visual circuit assembly in Drosophila. Photoreceptor axon targeting relies on a sequence of interdependent developmental steps to achieve temporal coordination with the formation and maturation of partner neurons. Distinct targeting events depend on anterograde and autocrine signaling, neuron-glia interactions, axon tiling and the timely expression of homophilic cell surface molecules. These mediate local adhesive or repulsive interactions of photoreceptor axons with each other and with target neurons.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Curr. Opin. Neurobiol.
    Title
    Current Opinion in Neurobiology
    Publication Year
    1991-
    ISBN/ISSN
    0959-4388
    Data From Reference