Reference Report

Reference
Citation	Narbonne-Reveau, K., Charroux, B., Royet, J. (2011). Lack of an antibacterial response defect in Drosophila toll-9 mutant. PLoS ONE 6(2): e17470. (Export to RIS)
FlyBase ID	FBrf0213211
Publication Type	Research paper
PubMed ID	21386906
PubMed Abstract	Toll and Toll-like receptors represent families of receptors involved in mediating innate immunity response in insects and mammals. Although Drosophila proteome contains multiple Toll paralogs, Toll-1 is, so far, the only receptor to which an immune role has been attributed. In contrast, every single mammalian TLR is a key membrane receptor upstream of the vertebrate immune signaling cascades. The prevailing view is that TLR-mediated immunity is ancient. Structural analysis reveals that Drosophila Toll-9 is the most closely related to vertebrate TLRs and utilizes similar signaling components as Toll-1. This suggests that Toll-9 could be an ancestor of TLR-like receptors and could have immune function. Consistently, it has been reported that over-expression of Toll-9 in immune tissues is sufficient to induce the expression of some antimicrobial peptides in flies. These results have led to the idea that Toll-9 could be a constitutively active receptor that maintain significant levels of antimicrobial molecules and therefore provide constant basal protection against micro-organisms. To test theses hypotheses, we generated and analyzed phenotypes associated with a complete loss-of-function allele of Toll-9. Our results suggest that Toll-9 is neither required to maintain a basal anti-microbial response nor to mount an efficient immune response to bacterial infection.
DOI	10.1371/journal.pone.0017470
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Language of Publication	English
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Publication Type	Journal
Abbreviation	PLoS ONE
Title	PLoS ONE
Publication Year	2006-
ISBN/ISSN	1932-6203
Data from Reference
Aberrations (1)
	Df(3L)rdgC-co2
Alleles (13)
	Avic\GFP^EGFP.Dpt Avic\GFP^{EGFP.Dro.JM877} Avic\GFP^S65T.CecA1 Avic\GFP^Scer\UAS.cUa Dpt^{Scer\UAS.T:Disc\RFP-mCherry} Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Rel^E20 Scer\GAL4^esg-NP5130 Scer\GAL4^lz-gal4 Scer\GAL4^srp.D.cCa spz⁴ Toll-9^KO Toll-9^Scer\UAS.cBa
Constructs (7)
	P{CecA1-GFP.JL164} P{Dpt-GFP.JM863} P{Dro-GFP.JM877} P{srpD-GAL4.C} P{UAS-Dpt-cherry} P{UAS-GFP.U} P{UAS-mCD8::GFP.L}
Genes (13)
	Avic\GFP Def Dpt Drs Drsl3 lz Mmus\Cd8a Rel Scer\GAL4 spz srp Tl Toll-9
Insertions (2)
	P{GawB}lz^gal4 P{GawB}NP5130
Natural transposons (1)
	P-element