Open Close
Reference
Citation
Shen, W.L., Kwon, Y., Adegbola, A.A., Luo, J., Chess, A., Montell, C. (2011). Function of rhodopsin in temperature discrimination in Drosophila.  Science 331(6022): 1333--1336.
FlyBase ID
FBrf0213227
Publication Type
Research paper
Abstract

Many animals, including the fruit fly, are sensitive to small differences in ambient temperature. The ability of Drosophila larvae to choose their ideal temperature (18°C) over other comfortable temperatures (19° to 24°C) depends on a thermosensory signaling pathway that includes a heterotrimeric guanine nucleotide-binding protein (G protein), a phospholipase C, and the transient receptor potential TRPA1 channel. We report that mutation of the gene (ninaE) encoding a classical G protein-coupled receptor (GPCR), Drosophila rhodopsin, eliminates thermotactic discrimination in the comfortable temperature range. This role for rhodopsin in thermotaxis toward 18°C was light-independent. Introduction of mouse melanopsin restored normal thermotactic behavior in ninaE mutant larvae. We propose that rhodopsins represent a class of evolutionarily conserved GPCRs that are required for initiating thermosensory signaling cascades.

PubMed ID
PubMed Central ID
Related Publication(s)
Note

Cell biology. Rhodopsin as thermosensor?
Minke and Peters, 2011, Science 331(6022): 1272--1273 [FBrf0214422]

Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Science
    Title
    Science
    Publication Year
    1895-
    ISBN/ISSN
    0036-8075 1095-9203
    Data From Reference