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Citation
Song, H., Goetze, S., Bischof, J., Spichiger-Haeusermann, C., Kuster, M., Brunner, E., Basler, K. (2010). Coop functions as a corepressor of Pangolin and antagonizes Wingless signaling.  Genes Dev. 24(9): 881--886.
FlyBase ID
FBrf0213249
Publication Type
Research paper
Abstract

Wingless (Wg) signaling regulates expression of its target genes via Pangolin and Armadillo, and their interacting cofactors. In the absence of Wg, Pangolin mediates transcriptional repression. In the presence of Wg, Pangolin, Armadillo, and a cohort of coactivators mediate transcriptional activation. Here we uncover Coop (corepressor of Pan) as a Pangolin-interacting protein. Coop and Pangolin form a complex on DNA containing a Pangolin/TCF-binding motif. Overexpression of Coop specifically represses Wg target genes, while loss of Coop function causes derepression. Finally, we show that Coop antagonizes the binding of Armadillo to Pangolin, providing a mechanism for Coop-mediated repression of Wg target gene transcription.

PubMed ID
PubMed Central ID
PMC2861187 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Genes Dev.
    Title
    Genes & Development
    Publication Year
    1987-
    ISBN/ISSN
    0890-9369
    Data From Reference
    Alleles (16)
    Gene Groups (1)
    Genes (20)
    Physical Interactions (1)
    Cell Lines (1)
    Natural transposons (1)
    Insertions (4)
    Experimental Tools (1)
    Transgenic Constructs (11)