Reference Report

Reference
Citation	Song, H., Goetze, S., Bischof, J., Spichiger-Haeusermann, C., Kuster, M., Brunner, E., Basler, K. (2010). Coop functions as a corepressor of Pangolin and antagonizes Wingless signaling. Genes Dev. 24(9): 881--886. (Export to RIS)
FlyBase ID	FBrf0213249
Publication Type	Research paper
PubMed ID	20439429
PubMed Abstract	Wingless (Wg) signaling regulates expression of its target genes via Pangolin and Armadillo, and their interacting cofactors. In the absence of Wg, Pangolin mediates transcriptional repression. In the presence of Wg, Pangolin, Armadillo, and a cohort of coactivators mediate transcriptional activation. Here we uncover Coop (corepressor of Pan) as a Pangolin-interacting protein. Coop and Pangolin form a complex on DNA containing a Pangolin/TCF-binding motif. Overexpression of Coop specifically represses Wg target genes, while loss of Coop function causes derepression. Finally, we show that Coop antagonizes the binding of Armadillo to Pangolin, providing a mechanism for Coop-mediated repression of Wg target gene transcription.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Genes Dev.
Title	Genes & Development
Publication Year	1987-
ISBN/ISSN	0890-9369
Data from Reference
Alleles (16)
	Adf1^Scer\UAS.cDa Avic\GFP^Scer\UAS.cUa Coop^EP Coop^GD6554 Coop^KK106968 Coop^R56 Coop^R62 Coop^Scer\UAS.cSa CTPsyn^Scer\UAS.cSa Ecol\lacZ^{salm-A405.1M2} Scer\GAL4^ap-md544 Scer\GAL4^dpp.blk1 Scer\GAL4^en-e16E Scer\GAL4^salm.E Scer\GAL4^{Scer\FRT.Rnor\CD2.Act5C} wg^hs.2sev
Constructs (11)
	P{EP} P{GAL4-Act5C(FRT.CD2).P} P{GAL4-dpp.blk1} P{GD6554} P{KK106968} P{salm-GAL4.E} P{sev-wg.B} P{UAS-Adf1.D} P{UAS-Coop.S} P{UAS-CTPsyn.S} P{UAS-GFP.U}
Genes (20)
	Adf1 Avic\GFP bi CG6234 Coop ct CtBP CTPsyn Dll dpp Ecol\lacZ gro lgs nkd Notum pan salm Scer\GAL4 sens wg
Insertions (4)
	P{en2.4-GAL4}e16E P{EP}Coop^EP P{GawB}ap^md544 P{lArB}salm^A405.1M2
Natural transposons (1)
	P-element