Reference Report

Reference
Citation	Brideau, N.J., Barbash, D.A. (2011). Functional conservation of the Drosophila hybrid incompatibility gene Lhr. BMC Evol. Biol. 11(): 57. (Export to RIS)
FlyBase ID	FBrf0213263
Publication Type	Research paper
PubMed ID	21366928
PubMed Abstract	Hybrid incompatibilities such as sterility and lethality are commonly modeled as being caused by interactions between two genes, each of which has diverged separately in one of the hybridizing lineages. The gene Lethal hybrid rescue (Lhr) encodes a rapidly evolving heterochromatin protein that causes lethality of hybrid males in crosses between Drosophila melanogaster females and D. simulans males. Previous genetic analyses showed that hybrid lethality is caused by D. simulans Lhr but not by D. melanogaster Lhr, confirming a critical prediction of asymmetry in the evolution of a hybrid incompatibility gene.Here we have examined the functional properties of Lhr orthologs from multiple Drosophila species, including interactions with other heterochromatin proteins, localization to heterochromatin, and ability to complement hybrid rescue in D. melanogaster/D. simulans hybrids. We find that these properties are conserved among most Lhr orthologs, including Lhr from D. melanogaster, D. simulans and the outgroup species D. yakuba.We conclude that evolution of the hybrid lethality properties of Lhr between D. melanogaster and D. simulans did not involve extensive loss or gain of functions associated with protein interactions or localization to heterochromatin.
DOI	10.1186/1471-2148-11-57
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Language of Publication	English
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Publication Type	Journal
Abbreviation	BMC Evol. Biol.
Title	BMC Evolutionary Biology
Publication Year	2001-
ISBN/ISSN	1471-2148
Data from Reference
Alleles (8)
	Dsim\Lhr¹ Dsim\Lhr^{C.Scer\UAS.T:Avic\GFP-YFP.Venus} Dvir\Lhr^{C.Scer\UAS.T:Avic\GFP-YFP.Venus} Dyak\Lhr^{C.Scer\UAS.T:Avic\GFP-YFP.Venus} Lhr^{C.Scer\UAS.T:Avic\GFP-YFP.Venus} Scer\GAL4^Act5C.PI Scer\GAL4^c729 T:Avic\GFP^YFP.Venus
Constructs (5)
	M{UAS-simLhr-YFP} M{UAS-virLhr-YFP} M{UAS-yakLhr-YFP} P{Act5C-GAL4} P{UAS-melLhr-YFP}
Genes (15)
	Dana\Lhr Dere\Lhr Dpse\Lhr Dsim\HP1A Dsim\HP6 Dsim\Lhr Dvir\Lhr Dyak\Lhr HP4 HP5 HP6 Lhr rhi Scer\GAL4 Su(var)205
Insertions (8)
	M{3xP3-RFP.attP}ZH-86Fb M{UAS-simLhr-YFP}ZH-86Fb M{UAS-virLhr-YFP}ZH-86Fb M{UAS-yakLhr-YFP}ZH-86Fb P{GawB}c729 P{UAS-melLhr-YFP}1 P{UAS-melLhr-YFP}2 P{UAS-melLhr-YFP}3
Natural transposons (2)
	Dmau\mariner P-element