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Citation
Pielage, J., Bulat, V., Zuchero, J.B., Fetter, R.D., Davis, G.W. (2011). Hts/Adducin controls synaptic elaboration and elimination.  Neuron 69(6): 1114--1131.
FlyBase ID
FBrf0213329
Publication Type
Research paper
Abstract

Neural development requires both synapse elaboration and elimination, yet relatively little is known about how these opposing activities are coordinated. Here, we provide evidence Hts/Adducin can serve this function. We show that Drosophila Hts/Adducin is enriched both pre- and postsynaptically at the NMJ. We then demonstrate that presynaptic Hts/Adducin is necessary and sufficient to control two opposing processes associated with synapse remodeling: (1) synapse stabilization as determined by light level and ultrastructural and electrophysiological assays and (2) the elaboration of actin-based, filopodia-like protrusions that drive synaptogenesis and growth. Synapse remodeling is sensitive to Hts/Adducin levels, and we provide evidence that the synaptic localization of Hts/Adducin is controlled via phosphorylation. Mechanistically, Drosophila Hts/Adducin protein has actin-capping activity. We propose that phosphorylation-dependent regulation of Hts/Adducin controls the level, localization, and activity of Hts/Adducin, influencing actin-based synapse elaboration and spectrin-based synapse stabilization. Hts/Adducin may define a mechanism to switch between synapse stability and dynamics.

PubMed ID
PubMed Central ID
PMC3073818 (PMC) (EuropePMC)
Related Publication(s)
Note

Memory, Synapse Stability, and β-Adducin.
Babic and Zinsmaier, 2011, Neuron 69(6): 1039--1041 [FBrf0213342]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Neuron
    Title
    Neuron
    Publication Year
    1988-
    ISBN/ISSN
    0896-6273
    Data From Reference