Reference Report

Reference
Citation	Tao, J., Rolls, M.M. (2011). Dendrites have a rapid program of injury-induced degeneration that is molecularly distinct from developmental pruning. J. Neurosci. 31(14): 5398--5405. (Export to RIS)
FlyBase ID	FBrf0213404
Publication Type	Research paper
PubMed ID	21471375
PubMed Abstract	Neurons have two types of processes: axons and dendrites. Axons have an active disassembly program activated by severing. It has not been tested whether dendrites have an analogous program. We sever Drosophila dendrites in vivo and find that they are cleared within 24 h. Morphologically, this clearance resembles developmental dendrite pruning and, to some extent, axon degeneration. Like axon degeneration, both injury-induced dendrite degeneration and pruning can be delayed by expression of Wld(s) or UBP2. We therefore hypothesized that they use common machinery. Surprisingly, comparison of dendrite pruning and degeneration in the same cell demonstrated that none of the specific machinery used to prune dendrites is required for injury-induced dendrite degeneration. In addition, we show that the rapid program of dendrite degeneration does not require mitochondria. Thus, dendrites do have a rapid program of degeneration, as do axons, but this program does not require the machinery used during developmental pruning.
DOI	10.1523/JNEUROSCI.3826-10.2011
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Language of Publication	English
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Publication Type	Journal
Abbreviation	J. Neurosci.
Title	Journal of Neuroscience
Publication Year	1981-
ISBN/ISSN	0270-6474 1529-2401
Data from Reference
Alleles (17)
	Avic\GFP^{S65T.Scer\UAS.T:Ivir\HA1,T:Hsap\mito} BacA\p35^Scer\UAS.cHa Dcr-2^Scer\UAS.cDa Eb1^{Scer\UAS.T:Avic\GFP-EGFP} ik2^KK102408 kat-60L1^GD7435 Mical^GD13442 Miro^KK102189 Mmus\Cd8a^{Scer\UAS.LG.T:Disc\RFP-mRFP} Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Mmus\wld^S.Scer\UAS Nc^GD12376 Scer\GAL4²²¹ Scer\GAL4^elav-C155 Scer\GAL4^ppk.1.9 Scer\UBP2^Scer\UAS.cDa th^Scer\UAS.cHa
Constructs (15)
	P{GD7435} P{GD12376} P{GD13442} P{KK102189} P{KK102408} P{ppk-GAL4.1.9} P{UAS-Dcr-2.D} P{UAS-DIAP1.H} P{UAS-Eb1.GFP} P{UAS-mCD8::GFP.L} P{UAS-mCD8.mRFP.LG} P{UAS-mito-HA-GFP.AP} P{UAS-p35.H} P{UAS-UBP2.D} P{UAS-wld.M}
Genes (14)
	Avic\GFP BacA\p35 Dcr-2 Eb1 ik2 kat-60L1 Mical Miro Mmus\Cd8a Mmus\wld Nc Scer\GAL4 Scer\UBP2 th
Insertions (2)
	P{GawB}221 P{GawB}elav^C155