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Citation
Roy, S., Hsiung, F., Kornberg, T.B. (2011). Specificity of Drosophila cytonemes for distinct signaling pathways.  Science 332(6027): 354--358.
FlyBase ID
FBrf0213449
Publication Type
Research paper
Abstract

Cytonemes are types of filopodia in the Drosophila wing imaginal disc that are proposed to serve as conduits in which morphogen signaling proteins move between producing and target cells. We investigated the specificity of cytonemes that are made by target cells. Cells in wing discs made cytonemes that responded specifically to Decapentaplegic (Dpp) and cells in eye discs made cytonemes that responded specifically to Spitz (the Drosophila epidermal growth factor protein). Tracheal cells had at least two types: one made in response to Branchless (a Drosophila fibroblast growth factor protein, Bnl), to which they segregate the Bnl receptor, and another to which they segregate the Dpp receptor. We conclude that cells can make several types of cytonemes, each of which responds specifically to a signaling pathway by means of the selective presence of a particular signaling protein receptor that has been localized to that cytoneme.

PubMed ID
PubMed Central ID
PMC3109072 (PMC) (EuropePMC)
Related Publication(s)
Note

Cell biology. Cytonemes show their colors.
Affolter and Basler, 2011, Science 332(6027): 312--313 [FBrf0214272]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Science
    Title
    Science
    Publication Year
    1895-
    ISBN/ISSN
    0036-8075
    Data From Reference