Reference Report

Reference
Citation	Suissa, Y., Ziv, O., Dinur, T., Arama, E., Gerlitz, O. (2011). The NAB-Brk Signal Bifurcates at JNK to Independently Induce Apoptosis and Compensatory Proliferation. J. Biol. Chem. 286(17): 15556--15564. (Export to RIS)
FlyBase ID	FBrf0213516
Publication Type	Research paper
PubMed ID	21385866
PubMed Abstract	Apoptosis operates to eliminate damaged or potentially dangerous cells. This loss is often compensated by extra proliferation of neighboring cells. Studies in Drosophila imaginal discs suggest that the signal for the additional growth emanates from the dying cells. In particular, it was suggested that the initiator caspase Dronc mediates compensatory proliferation (CP) through Dp53 in wing discs. However, the exact mechanism that governs this CP remained poorly understood. We have previously shown that elimination of misspecified cells due to reduced Dpp signaling is achieved by the interaction of the co-repressor NAB with the transcriptional repressor Brk, which in turn induces Jun N-terminal kinase-dependent apoptosis. Here, we performed a systematic in vivo loss- and gain-of-function analysis to study NAB-induced death and CP. Our findings indicate that the NAB primary signal activates JNK, which in turn transmits two independent signals. One triggers apoptosis through the pro-apoptotic proteins Reaper and Hid, which in turn promote activation of caspases by the apoptosome components Ark and Dronc. The other signal induces CP in a manner that is independent of the death signal, Dronc, or Dp53. Once induced, the apoptotic pathway further activates a CP response. Our data suggest that JNK is the candidate factor that differentiates between apoptosis that involves CP and apoptosis that does not.
DOI	10.1074/jbc.M110.193235
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Language of Publication	English
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Publication Type	Journal
Abbreviation	J. Biol. Chem.
Title	Journal of Biological Chemistry
Publication Year	1905-
ISBN/ISSN	0021-9258
Data from Reference
Aberrations (2)
	Df(3L)H99 Df(3L)XR38
Alleles (18)
	Ark^L46 BacA\p35^Scer\UAS.cHa brk^GD1390 Dredd^F64 Dredd^L23 Ecol\lacZ^puc-E69 grim^GD11287 nab^EP-nd642 Nc^NIG.8091R p53^{D259H.Scer\UAS} puc^Scer\UAS.cMa Scer\GAL4^ap-nd432 Scer\GAL4^hh-nd271 Scer\GAL4^nd642 Scer\GAL4^{Scer\FRT.Rnor\CD2.Act5C} Scer\GAL4^sd.PU th^EP.M W⁰⁵⁰¹⁴
Constructs (10)
	P{EP} P{GAL4-Act5C(FRT.CD2).P} P{GalW} P{GD1390} P{GD11287} P{NIG.8091R} P{sd-GAL4.U} P{UAS-p35.H} P{UAS-p53.D259H} P{UAS-puc.M}
Genes (17)
	Ark BacA\p35 brk bsk decay Dredd Ecol\lacZ grim nab Nc p53 puc rpr Scer\GAL4 th W wg
Insertions (7)
	P{A92}puc^E69 P{EP.Scer\UAS(loxP.Scer\UAS.y⁺).BN}th^EP.M P{EP}nab^EP-nd642 P{GalW}ap^nd432 P{GalW}hh^nd271 P{GalW}nd642 P{PZ}W⁰⁵⁰¹⁴
Natural transposons (1)
	P-element