Reference Report

Reference
Citation	König, A., Yatsenko, A.S., Weiss, M., Shcherbata, H.R. (2011). Ecdysteroids affect Drosophila ovarian stem cell niche formation and early germline differentiation. EMBO J. 30(8): 1549--1562. (Export to RIS)
FlyBase ID	FBrf0213531
Publication Type	Research paper
PubMed ID	21423150
PubMed Abstract	Previously, it has been shown that in Drosophila steroid hormones are required for progression of oogenesis during late stages of egg maturation. Here, we show that ecdysteroids regulate progression through the early steps of germ cell lineage. Upon ecdysone signalling deficit germline stem cell progeny delay to switch on a differentiation programme. This differentiation impediment is associated with reduced TGF-β signalling in the germline and increased levels of cell adhesion complexes and cytoskeletal proteins in somatic escort cells. A co-activator of the ecdysone receptor, Taiman is the spatially restricted regulator of the ecdysone signalling pathway in soma. Additionally, when ecdysone signalling is perturbed during the process of somatic stem cell niche establishment enlarged functional niches able to host additional stem cells are formed.
DOI	10.1038/emboj.2011.73
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Language of Publication	English
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Publication Type	Journal
Abbreviation	EMBO J.
Title	The EMBO Journal
Publication Year	1982-
ISBN/ISSN	0261-4189
Data from Reference
Alleles (25)
	ab^Scer\UAS.cBa Avic\GFP^tai-G00308 ecd¹ Ecol\lacZ^Adh.EcRE EcR^A.hs EcR^A.Scer\UAS EcR^B1.hs EcR^B1.Scer\UAS EcR^{dsRNA.Scer\UAS.cCa} EcR^{hs.T:Scer\GAL4} EcR^M554fs EcR^Q50st Scer\GAL4^Act.PU Scer\GAL4^bab1-Pgal4-2 Scer\GAL4^ptc-559.1 Scer\GAL80^ts.αTub84B tai^61G1 tai⁰¹³⁵¹ tai^BG02711 tai^EY11718 tai^GD4265 tai^k15101 tai^KG02309 usp⁴ usp^{hs.T:Scer\GAL4}
Constructs (12)
	P{EcRE.lacZ} P{GD4265} P{hs-EcR.A} P{hs-EcR.B1} P{hs-GAL4-EcR.LBD} P{hs-GAL4-usp.LBD} P{PTT-un1} P{tubP-GAL80^ts} P{UAS-ab.B} P{UAS-EcR.A} P{UAS-EcR.B1} P{UAS-EcR-RNAi}
Genes (16)
	ab arm Avic\GFP bam Dad ecd Ecol\lacZ EcR hts LamC Mad Scer\GAL4 Scer\GAL80 tai usp vas
Insertions (3)
	P{GawB}bab1^Pgal4-2 P{GawB}ptc^559.1 P{PTT-un1}tai^G00308