Reference Report

Reference
Citation	Keene, A.C., Mazzoni, E.O., Zhen, J., Younger, M.A., Yamaguchi, S., Blau, J., Desplan, C., Sprecher, S.G. (2011). Distinct visual pathways mediate Drosophila larval light avoidance and circadian clock entrainment. J. Neurosci. 31(17): 6527--6534. (Export to RIS)
FlyBase ID	FBrf0213587
Publication Type	Research paper
PubMed ID	21525293
PubMed Abstract	Visual organs perceive environmental stimuli required for rapid initiation of behaviors and can also entrain the circadian clock. The larval eye of Drosophila is capable of both functions. Each eye contains only 12 photoreceptors (PRs), which can be subdivided into two subtypes. Four PRs express blue-sensitive rhodopsin5 (rh5) and eight express green-sensitive rhodopsin6 (rh6). We found that either PR-subtype is sufficient to entrain the molecular clock by light, while only the Rh5-PR subtype is essential for light avoidance. Acetylcholine released from PRs confers both functions. Both subtypes of larval PRs innervate the main circadian pacemaker neurons of the larva, the neuropeptide PDF (pigment-dispersing factor)-expressing lateral neurons (LNs), providing sensory input to control circadian rhythms. However, we show that PDF-expressing LNs are dispensable for light avoidance, and a distinct set of three clock neurons is required. Thus we have identified distinct sensory and central circuitry regulating light avoidance behavior and clock entrainment. Our findings provide insights into the coding of sensory information for distinct behavioral functions and the underlying molecular and neuronal circuitry.
DOI	10.1523/JNEUROSCI.6165-10.2011
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Language of Publication	English
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Publication Type	Journal
Abbreviation	J. Neurosci.
Title	Journal of Neuroscience
Publication Year	1981-
ISBN/ISSN	0270-6474 1529-2401
Data from Reference
Alleles (25)
	Avic\GFP^E.Rh6 Bmul\αBgtx^Scer\UAS.cKa Cha^{dsRNA.Scer\UAS} cry^b Ecol\lacZ^Rh5.-560 Ecol\lacZ^Rh6.-555+121 Hsap\HIST2H2BE^{Scer\UAS.T:Avic\GFP-YFP} Hsap\KCNJ2^{Scer\UAS.T:Avic\GFP-EGFP} Mmus\Cd8a^{Scer\FRT.Scer\UAS.T:Avic\GFP} Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Rh5² Rh6¹ rpr^Scer\UAS.C Scer\GAL4^Cha.7.4 Scer\GAL4^cry.PZ Scer\GAL4^elav-C155 Scer\GAL4^GMR.PFa Scer\GAL4^P2.4.Pdf Scer\GAL4^Rh5.PT Scer\GAL4^Rh6.PD Scer\GAL4^tim.PE Scer\GAL80^cry.PS Scer\GAL80^Pdf.PS shi^1.Scer\UAS W^Scer\UAS.cUa
Constructs (21)
	P{Cha-GAL4.7.4} P{cry-GAL4.Z} P{cry-GAL80.S} P{GAL4-tim.E} P{GMR-GAL4.w^-} P{Pdf-GAL4.P2.4} P{Pdf-GAL80.S} P{Rh5-GAL4} P{Rh5-lacZ.-560} P{Rh6-EGFP.P} P{Rh6-GAL4.D} P{Rh6-lacZ.-555+121} P{UAS(FRT.CD2.y⁺)CD8-GFP} P{UAS-Cha.dsRNA} P{UAS-H2B-T:Avic\GFP-YFP} P{UAS-Hsap\KCNJ2.EGFP} P{UAS-mCD8::GFP.L} P{UAS-rpr.C} P{UAS-shi^ts1.K} P{UAS-W.U} P{UAS-αBtx}
Genes (23)
	Avic\GFP Bmul\αBgtx brp Cha chp cry Ecol\lacZ elav Fas2 futsch Hsap\HIST2H2BE Hsap\KCNJ2 Mmus\Cd8a Pdf Rh5 Rh6 rpr Scer\GAL4 Scer\GAL80 shi T:Hsap\MYC tim W
Insertions (1)
	P{GawB}elav^C155
Natural transposons (1)
	P-element
Transcripts (3)
	Avic\GFP^E.Rh6RA Ecol\lacZ^Rh5.-560RA Scer\GAL4^Cha.7.4RA