|Citation||Shuai, Y., Zhang, Y., Gao, L., Zhong, Y. (2011). Stress Resistance Conferred by Neuronal Expression of Dominant-Negative Rac in Adult Drosophila melanogaster. J. Neurogenet. 25(1-2): 35--39. (Export to RIS)|
|Publication Type||Research paper|
|PubMed Abstract||How does brain coordinate physiological and behavioral responses to achieve survival in adverse environment is intriguing yet complicated. During studies of the small G protein Rac's role in learning and memory, the authors unexpectedly observed that neuronal expression of dominant-negative Rac in adult Drosophila remarkably enhanced the survival of animals in various stress conditions, including oxidation, desiccation, starvation, and heat. The elevated stress resistance was not accompanied by a reduction in female fecundity or a change in whole-body lipid storage. The observation therefore implies the involvement of small G protein Rac in neuronal regulation of global stress responses.|
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|Language of Publication||English|
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|Title||Journal of Neurogenetics|
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