Reference Report

Reference
Citation	Vargas, R.H., Ornelas, L.F., González, I.L., Escovar, J.R., Zurita, M., Reynaud, E. (2011). Synphilin suppresses α-synuclein neurotoxicity in a Parkinson's disease Drosophila model. genesis 49(5): 392--402. (Export to RIS)
FlyBase ID	FBrf0213669
Publication Type	Research paper
PubMed ID	21584925
PubMed Abstract	Parkinson's disease (PD) is the second most common neurodegenerative disorder in humans. It affects 1% of the population over 65-years old. Its causes are environmental and genetic. As the world population ages, there is an urgent need for better and more detailed animal models for this kind of disease. In this work we show that the use of transgenic Drosophila is comparable to more complicated and costly animal models such as mice. The Drosophila model behaves very similar to the equivalent transgenic mice model. We show that both Synphilin-1 and α-synuclein are toxic by themselves, but when co-expressed, they suppress their toxicity reciprocally. Importantly, the symptoms induced in the fly can be treated and partially reverted using standard PD pharmacological treatments. This work showcases Drosophila as a detailed and multifaceted model for Parkinson's disease, providing a convenient platform in which to study and find new genetic modifiers of PD. genesis 49:392-402, 2011.
DOI	10.1002/dvg.20740
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	genesis
Title	genesis
Publication Year	2000-
ISBN/ISSN	1526-954X 1526-968X
Data from Reference
Alleles (7)
	Hsap\SNCA^{A30P.Scer\UAS} Hsap\SNCA^{A53T.Scer\UAS} Hsap\SNCA^Scer\UAS.cFa Hsap\SNCAIP^Scer\UAS.cHa Scer\GAL4^elav-C155 Scer\GAL4^ple.PF Scer\GAL4^unspecified
Constructs (5)
	P{ple-GAL4.F} P{UAS-Hsap\SNCA.A30P} P{UAS-Hsap\SNCA.A53T} P{UAS-Hsap\SNCA.F} P{UAS-sinf.H}
Genes (3)
	Hsap\SNCA Hsap\SNCAIP Scer\GAL4
Insertions (3)
	P{GawB}elav^C155 P{UAS-sinf.H}7 P{UAS-sinf.H}9
Natural transposons (1)
	P-element