Reference Report

Reference
Citation	Copf, T., Goguel, V., Lampin-Saint-Amaux, A., Scaplehorn, N., Preat, T. (2011). Cytokine signaling through the JAK/STAT pathway is required for long-term memory in Drosophila. Proc. Natl. Acad. Sci. U.S.A. 108(19): 8059--8064. (Export to RIS)
FlyBase ID	FBrf0213703
Publication Type	Research paper
PubMed ID	21518857
PubMed Abstract	Cytokine signaling through the JAK/STAT pathway regulates multiple cellular responses, including cell survival, differentiation, and motility. Although significant attention has been focused on the role of cytokines during inflammation and immunity, it has become clear that they are also implicated in normal brain function. However, because of the large number of different genes encoding cytokines and their receptors in mammals, the precise role of cytokines in brain physiology has been difficult to decipher. Here, we took advantage of Drosophila's being a genetically simpler model system to address the function of cytokines in memory formation. Expression analysis showed that the cytokine Upd is enriched in the Drosophila memory center, the mushroom bodies. Using tissue- and adult-specific expression of RNAi and dominant-negative proteins, we show that not only is Upd specifically required in the mushroom bodies for olfactory aversive long-term memory but the Upd receptor Dome, as well as the Drosophila JAK and STAT homologs Hop and Stat92E, are also required, while being dispensable for less stable memory forms.
DOI	10.1073/pnas.1012919108
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Proc. Natl. Acad. Sci. U.S.A.
Title	Proceedings of the National Academy of Sciences of the United States of America
Publication Year	1915-
ISBN/ISSN	0027-8424
Data from Reference
Alleles (16)
	dome^{dsRNA.Scer\UAS.cCa} dome^{ΔCYT.Scer\UAS} hop^{dsRNA.Scer\UAS.cCa} os^NIG.5993R Scer\GAL4^238Y Scer\GAL4^c739 Scer\GAL4^ey-OK107 Scer\GAL4^{Mef2.247.Switch} Scer\GAL4^Mef2.247 Scer\GAL4^upd-E132 Scer\GAL80^ts.αTub84B Socs36E^{Scer\UAS.P\T.cCa} Socs36E^{SH2.Scer\UAS.P\T} Stat92E^{M647H.Scer\UAS.T:Avic\GFP-EGFP} Stat92E^NIG.4257R Stat92E^ΔN.Scer\UAS
Constructs (12)
	P{MB-Switch} P{Mef2-GAL4.247} P{NIG.4257R} P{NIG.5993R} P{tubP-GAL80^ts} P{UAS-dome.RNAi} P{UAS-dome.ΔCYT} P{UAS-hop.RNAi} P{UASp-Socs36E.C} P{UASp-Socs36E.SH2} P{UAS-Stat92E.EGFP.M647H} P{UAS-Stat92E.ΔN}
Genes (8)
	dome Fas2 hop os Scer\GAL4 Scer\GAL80 Socs36E Stat92E
Insertions (4)
	P{GawB}238Y P{GawB}E132 P{GawB}ey^OK107 P{GawB}Hr39^c739
Natural transposons (1)
	P-element