Reference Report

Reference
Citation	Yuva-Aydemir, Y., Bauke, A.C., Klämbt, C. (2011). Spinster Controls Dpp Signaling during Glial Migration in the Drosophila Eye. J. Neurosci. 31(19): 7005--7015. (Export to RIS)
FlyBase ID	FBrf0213705
Publication Type	Research paper
PubMed ID	21562262
PubMed Abstract	The development of multicellular organisms requires the well balanced and coordinated migration of many cell types. This is of particular importance within the developing nervous system, where glial cells often move long distances to reach their targets. The majority of glial cells in the peripheral nervous system of the Drosophila embryo is derived from the CNS and migrates along motor axons toward their targets. In the developing Drosophila eye, CNS-derived glial cells move outward toward the nascent photoreceptor cells, but the molecular mechanisms coupling the migration of glial cells with the growth of the eye imaginal disc are mostly unknown. Here, we used an enhancer trap approach to identify the gene spinster, which encodes a multipass transmembrane protein involved in endosome-lysosome trafficking, as being expressed in many glial cells. spinster mutants are characterized by glial overmigration. Genetic experiments demonstrate that Spinster modulates the activity of several signaling cascades. Within the migrating perineurial glial cells, Spinster is required to downregulate Dpp (Decapentaplegic) signaling activity, which ceases migratory abilities. In addition, Spinster affects the growth of the carpet cell, which indirectly modulates glial migration.
DOI	10.1523/JNEUROSCI.0459-11.2011
Related Publication(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	J. Neurosci.
Title	Journal of Neuroscience
Publication Year	1981-
ISBN/ISSN	0270-6474 1529-2401
Data from Reference
Aberrations (1)
	Df(2R)Jp6
Alleles (47)
	Avic\GFP^{tkv-CPTI002487} bchs^VDRC.cUa Chc^VDRC.cUa dome⁶⁰⁴⁴¹ dpp^d6 dpp^d12 Eps-15^VDRC.cUa hh^AC hk¹ hk^GD12598 Hrs^D28 Hrs^VDRC.cUa Mad^8-2 or^49h or^VDRC.cUa os^upd-4 ptc⁹ put¹⁰⁴⁶⁰ Rab7^GD11800 Rab11^VDRC.cUa rb¹ rb^VDRC.cUa sax^KG07525 Scer\GAL4^c527 Scer\GAL4^da.G32 Scer\GAL4^elav.PU Scer\GAL4^ey.3.5.Exel Scer\GAL4^moody.SPG Scer\GAL4^Mz97 Scer\GAL4^repo.PU Scer\GAL4^spin-15IIa Scer\GAL4^spin.PN shi^{ts.Scer\UAS.cUa} spin^11F5 spin^15IIa spin¹⁰⁴⁰³ spin^I.Scer\UAS spin^k09905 spin^VDRC.cUa spin^Δ2b tkv¹ tkv⁷ tkv^VDRC.cUa Vps16A^VDRC.cUa Vps25^VDRC.cUa wg^l-8 wit^B11
Constructs (22)
	P{elav-GAL4.U} P{ey3.5-GAL4.Exel} P{GAL4} P{GAL4-da.G32} P{GD11800} P{GD12598} P{moody-GAL4.SPG} P{repo-GAL4.U} P{spin-GAL4.N} P{UAS-shi.ts.U} P{UAS-spin.I} P{VDRC.bchs.U} P{VDRC.Chc.U} P{VDRC.Eps-15.U} P{VDRC.Hrs.U} P{VDRC.or.U} P{VDRC.Rab11.U} P{VDRC.rb.U} P{VDRC.spin.U} P{VDRC.tkv.U} P{VDRC.Vps16A.U} P{VDRC.Vps25.U}
Genes (31)
	Avic\GFP bchs Chc dome dpp Eps-15 hh hk Hrs htl Mad or os ptc put Rab5 Rab7 Rab11 rb repo rl sax Scer\GAL4 shi spin Syx7 tkv Vps16A Vps25 wg wit
Insertions (6)
	P{GAL4}spin^15IIa P{GawB}c527 P{GawB}Mz97 P{lacW}spin^k09905 P{PZ}spin¹⁰⁴⁰³ PBac{544.SVS-1}tkv^CPTI002487
Natural transposons (1)
	P-element
Transcripts (4)
	Avic\GFP^{tkv-CPTI002487}RA Scer\GAL4^moody.SPGRA Scer\GAL4^spin-15IIaRA Scer\GAL4^spin.PNRA