Reference Report

Reference
Citation	Pitman, J.L., Huetteroth, W., Burke, C.J., Krashes, M.J., Lai, S.L., Lee, T., Waddell, S. (2011). A pair of inhibitory neurons are required to sustain labile memory in the Drosophila mushroom body. Curr. Biol. 21(10): 855--861. (Export to RIS)
FlyBase ID	FBrf0213725
Publication Type	Research paper
PubMed ID	21530258
PubMed Abstract	Labile memory is thought to be held in the brain as persistent neural network activity. However, it is not known how biologically relevant memory circuits are organized and operate. Labile and persistent appetitive memory in Drosophila requires output after training from the α'β' subset of mushroom body (MB) neurons and from a pair of modulatory dorsal paired medial (DPM) neurons. DPM neurons innervate the entire MB lobe region and appear to be pre- and postsynaptic to the MB, consistent with a recurrent network model. Here we identify a role after training for synaptic output from the GABAergic anterior paired lateral (APL) neurons. Blocking synaptic output from APL neurons after training disrupts labile memory but does not affect long-term memory. APL neurons contact DPM neurons most densely in the α'β' lobes, although their processes are intertwined and contact throughout all of the lobes. Furthermore, APL contacts MB neurons in the α' lobe but makes little direct contact with those in the distal α lobe. We propose that APL neurons provide widespread inhibition to stabilize and maintain synaptic specificity of a labile memory trace in a recurrent DPM and MB α'β' neuron circuit.
DOI	10.1016/j.cub.2011.03.069
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Curr. Biol.
Title	Current Biology
Publication Year	1991-
ISBN/ISSN	0960-9822
Data from Reference
Alleles (16)
	Avic\GFP^{spGFP1-10.Scer\UAS.T:Hsap\CD4} Avic\GFP^{spGFP11.Ecol\lexAop.T:Hsap\CD4} brp^{Scer\UAS.T:Avic\GFP} Ecol\lexA^L0111 Ecol\lexA^{Mef2.247.T:Hsim\VP16} Mmus\Cd8a^{Ncra\QUAS.T:Avic\GFP} Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Mmus\Cd8a^{Scer\UAS.T:Disc\RFP-mCherry} Ncra\QF^GH146.PP Scer\GAL4^c316 Scer\GAL4^GH146 Scer\GAL4^NP0225 Scer\GAL4^NP2631 Scer\GAL4^NP5288 Scer\GAL80^Cha.PK shi^1.Scer\UAS
Constructs (10)
	P{Cha-GAL80.K} P{lexAop-CD4-spGFP11} P{Mef2-LexA-VP16.247} P{QUAS-mCD8-GFP.P} P{UAS-brp.GFP} P{UAS-CD4-spGFP1-10} P{UAS-mCD8::GFP.L} P{UAS-mCD8.ChRFP} P{UAS-shi^ts1.K} PBac{GH146-QF.P}
Genes (10)
	Avic\GFP brp Disc\RFP Ecol\lexA Mmus\Cd8a Ncra\QF Scer\GAL4 Scer\GAL80 shi T:Hsim\VP16
Insertions (6)
	P{GawB}c316 P{GawB}GH146 P{GawB}NP0225 P{GawB}NP2631 P{GawB}NP5288 P{UAS-lexA-GAD}L0111
Natural transposons (1)
	P-element
Transcripts (4)
	Scer\GAL4^c316RA Scer\GAL4^GH146RA Scer\GAL4^NP2631RA Scer\GAL4^NP5288RA