Reference Report

Reference
Citation	Eddison, M., Guarnieri, D.J., Cheng, L., Liu, C.H., Moffat, K.G., Davis, G., Heberlein, U. (2011). arouser Reveals a Role for Synapse Number in the Regulation of Ethanol Sensitivity. Neuron 70(5): 979--990. (Export to RIS)
FlyBase ID	FBrf0213908
Publication Type	Research paper
PubMed ID	21658589
PubMed Abstract	A reduced sensitivity to the sedating effects of alcohol is a characteristic associated with alcohol use disorders (AUDs). A genetic screen for ethanol sedation mutants in Drosophila identified arouser (aru), which functions in developing neurons to reduce ethanol sensitivity. Genetic evidence suggests that aru regulates ethanol sensitivity through its activation by Egfr/Erk signaling and its inhibition by PI3K/Akt signaling. The aru mutant also has an increased number of synaptic terminals in the larva and adult fly. Both the increased ethanol sensitivity and synapse number of the aru mutant are restored upon adult social isolation, suggesting a causal relationship between synapse number and ethanol sensitivity. We thus show that a developmental abnormality affecting synapse number and ethanol sensitivity is not permanent and can be reversed by manipulating the environment of the adult fly.
DOI	10.1016/j.neuron.2011.03.030
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Secondary IDs
Language of Publication	English
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Publication Type	Journal
Abbreviation	Neuron
Title	Neuron
Publication Year	1988-
ISBN/ISSN	0896-6273
Data from Reference
Alleles (21)
	Akt1^EY10012 Akt1^KK100495 Akt1^{Scer\UAS.Exel} aru^8.128 aru^d08896 aru^{dsRNA.Scer\UAS} aru^GD11269 Avic\GFP^{S65T.Scer\UAS} Egfr^Scer\UAS.cBa hppy^17-51 Pdk1^EP837 Pi3K92E^{A2860C.Scer\UAS} Pi3K92E^{Scer\UAS.Exel} Pten^Scer\UAS.cGb Rheb^Scer\UAS.cPa rl^{Sem.C.Scer\UAS} Scer\GAL4^elav-C155 Scer\GAL4^P2.4.Pdf Scer\GAL4^tub.PU Scer\GAL80^ts.αTub84B Syt1^{Scer\UAS.T:Avic\GFP-EGFP}
Constructs (17)
	P{GawB} P{GD11269} P{KK100495} P{Pdf-GAL4.P2.4} P{tub-GAL4.U} P{tubP-GAL80^ts} P{UAS-Akt1.Exel} P{UAS-aru.dsRNA} P{UAS-Egfr.B} P{UAS-GFP.S65T} P{UAS-Pi3K92E.A2860C} P{UAS-Pi3K92E.Exel} P{UAS-Pten.Gb} P{UAS-Rheb.Pa} P{UAS-rl^Sem} P{UAS-syt.eGFP} P{XP}
Genes (14)
	Akt1 amn aru Avic\GFP Egfr hppy Pdk1 Pi3K92E Pten Rheb rl Scer\GAL4 Scer\GAL80 Syt1
Insertions (6)
	P{EP}Pdk1^EP837 P{EPgy2}Akt1^EY10012 P{GawB}aru^8.128 P{GawB}elav^C155 P{GawB}hppy^17-51 P{XP}aru^d08896
Natural transposons (1)
	P-element