Reference Report

Reference
Citation	van Eyk, C.L., O'Keefe, L.V., Lawlor, K.T., Samaraweera, S.E., McLeod, C.J., Price, G.R., Venter, D.J., Richards, R.I. (2011). Perturbation of the Akt/Gsk3-{beta} signalling pathway is common to Drosophila expressing expanded untranslated CAG, CUG and AUUCU repeat RNAs. Hum. Mol. Genet. 20(14): 2783--2794. (Export to RIS)
FlyBase ID	FBrf0213942
Publication Type	Research paper
PubMed ID	21518731
PubMed Abstract	Recent evidence supports a role for RNA as a common pathogenic agent in both the 'polyglutamine' and 'untranslated' dominant expanded repeat disorders. One feature of all repeat sequences currently associated with disease is their predicted ability to form a hairpin secondary structure at the RNA level. In order to investigate mechanisms by which hairpin-forming repeat RNAs could induce neurodegeneration, we have looked for alterations in gene transcript levels as hallmarks of the cellular response to toxic hairpin repeat RNAs. Three disease-associated repeat sequences--CAG, CUG and AUUCU--were specifically expressed in the neurons of Drosophila and resultant common transcriptional changes assessed by microarray analyses. Transcripts that encode several components of the Akt/Gsk3-β signalling pathway were altered as a consequence of expression of these repeat RNAs, indicating that this pathway is a component of the neuronal response to these pathogenic RNAs and may represent an important common therapeutic target in this class of diseases.
DOI	10.1093/hmg/ddr177
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Hum. Mol. Genet.
Title	Human Molecular Genetics
Publication Year	1992-
ISBN/ISSN	0964-6906
Data from Reference
Alleles (15)
	Hsap\ATXN10^{rAUUCU.65.Scer\UAS} Mef2^GD5039 mod(mdg4)^GD16547 Scer\GAL4^elav.PLu Scer\GAL4^elav-C155 Scer\GAL4^GMR.PFa sgg^KK108994 sgg^Scer\UAS.cBa Zzzz\CAG^{93.Scer\UAS.T:Hsap\MYC,T:Zzzz\FLAG} Zzzz\CAG^{CAA.94.Scer\UAS.T:Hsap\MYC,T:Zzzz\FLAG} Zzzz\CAG^{term93.Scer\UAS} Zzzz\CAG^{term.CAA.114.Scer\UAS} Zzzz\CTG^{84.Scer\UAS.T:Hsap\MYC,T:Zzzz\FLAG} Zzzz\CTG^{86.Scer\UAS.T:Hsap\MYC,T:Zzzz\FLAG} Zzzz\CTG^{term.CTG.99.Scer\UAS}
Constructs (14)
	P{GAL4-elav.L} P{GD5039} P{GD16547} P{GMR-GAL4.w^-} P{KK108994} P{UAS-CAA.94} P{UAS-CAG.93} P{UAS-CAG.term93} P{UAS-CTG.84} P{UAS-CTG.86} P{UAS-rAUUCU.65} P{UAS-rCAA.term114} P{UAS-rCUG.term99} P{UAS-sgg.B}
Genes (19)
	bw CG31871 ctp Def Hr38 Hsap\ATXN10 hts insc mbl Mef2 mod(mdg4) nej Scer\GAL4 sgg stau T:Hsap\MYC T:Zzzz\FLAG Zzzz\CAG Zzzz\CTG
Insertions (1)
	P{GawB}elav^C155
Natural transposons (1)
	P-element