Reference Report

Reference
Citation	Arancio, W., Onorati, M.C., Burgio, G., Collesano, M., Ingrassia, A.M.R., Genovese, S.I., Fanto, M., Corona, D.F.V. (2010). The nucleosome remodeling factor ISWI functionally interacts with an evolutionarily conserved network of cellular factors. Genetics 185(1): 129--140. (Export to RIS)
FlyBase ID	FBrf0213976
Publication Type	Research paper
PubMed ID	20194965
PubMed Abstract	ISWI is an evolutionarily conserved ATP-dependent chromatin remodeling factor playing central roles in DNA replication, RNA transcription, and chromosome organization. The variety of biological functions dependent on ISWI suggests that its activity could be highly regulated. Our group has previously isolated and characterized new cellular activities that positively regulate ISWI in Drosophila melanogaster. To identify factors that antagonize ISWI activity we developed a novel in vivo eye-based assay to screen for genetic suppressors of ISWI. Our screen revealed that ISWI interacts with an evolutionarily conserved network of cellular and nuclear factors that escaped previous genetic and biochemical analyses.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Genetics
Title	Genetics
Publication Year	1916-
ISBN/ISSN	0016-6731
Data from Reference
Alleles (17)
	Acf1¹ brm² casp^PBacG75α E(bx)^Nurf301-2 eff^e01950 eff^EP3627 Iswi² Iswi^+t12 Iswi^{K159R.T:Ivir\HA1} kis¹ mbf1^EP3684 mbf1^f05959 Scer\GAL4^ey.PH ttk^d02388 ttk^EP3314 wun^d04014 wun^PBacF48
Constructs (4)
	P{GAL4-ey.H} P{Iswi⁺.B12} P{Iswi^{K159R.T:Ivir\HA1}} PBac{3xP3-EYFP,p-tTA-K10}
Genes (108)
	Acf1 aralar1 Atx2 blot brm casp CG3092 CG4294 CG5180 CG5555 CG5789 CG5807 CG6051 CG6650 CG7420 CG7430 CG7560 CG8219 CG8420 CG9287 CG10426 CG11652 CG11873 CG12862 CG13623 CG13895 CG14508 CG15128 CG15425 CG17593 CG17732 CG18869 CG31475 CG33523 Chd64 chn cpo Cpr31A CR31044 crc DNApol-δ Doa dsd E2f E(bx) E(Pc) eff Eip75B Eip78C emc eRF1 exba fax Fer2LCH Gclm GlcAT-P hdc Hsp27 Hsrω ird1 Iswi Jheh2 Kdm2 kis lark Lk6 LysB Madm mbc mbf1 mir-279 mir-282 Mkp3 Mms19 mor mrn mura ninaE Nrx-IV olf413 osa Patr-1 Pdk1 Pen poly pum RasGAP1 RhoGAP68F RhoL RpL40 Rpn9 Scer\GAL4 slif slmb SNF4Aγ Spec2 sqd Ssdp stg tankyrase Tektin-C trx Tsp96F ttk Ube3a vig2 wdb wun
Insertions (9)
	P{EP}eff^EP3627 P{EP}mbf1^EP3684 P{EP}ttk^EP3314 P{XP}ttk^d02388 P{XP}wun^d04014 PBac{3xP3-EYFP,p-tTA-K10}casp^PBacG75α PBac{3xP3-EYFP,p-tTA-K10}wun^PBacF48 PBac{RB}eff^e01950 PBac{WH}mbf1^f05959