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Citation
Arancio, W., Onorati, M.C., Burgio, G., Collesano, M., Ingrassia, A.M.R., Genovese, S.I., Fanto, M., Corona, D.F.V. (2010). The nucleosome remodeling factor ISWI functionally interacts with an evolutionarily conserved network of cellular factors.  Genetics 185(1): 129--140.
FlyBase ID
FBrf0213976
Publication Type
Research paper
Abstract

ISWI is an evolutionarily conserved ATP-dependent chromatin remodeling factor playing central roles in DNA replication, RNA transcription, and chromosome organization. The variety of biological functions dependent on ISWI suggests that its activity could be highly regulated. Our group has previously isolated and characterized new cellular activities that positively regulate ISWI in Drosophila melanogaster. To identify factors that antagonize ISWI activity we developed a novel in vivo eye-based assay to screen for genetic suppressors of ISWI. Our screen revealed that ISWI interacts with an evolutionarily conserved network of cellular and nuclear factors that escaped previous genetic and biochemical analyses.

PubMed ID
PubMed Central ID
PMC2870949 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Genetics
    Title
    Genetics
    Publication Year
    1916-
    ISBN/ISSN
    0016-6731
    Data From Reference