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Citation
Awasaki, T., Huang, Y., O'Connor, M.B., Lee, T. (2011). Glia instruct developmental neuronal remodeling through TGF-β signaling.  Nat. Neurosci. 14(7): 821--823.
FlyBase ID
FBrf0213992
Publication Type
Research paper
Abstract

We found that glia secrete myoglianin, a TGF-β ligand, to instruct developmental neural remodeling in Drosophila. Glial myoglianin upregulated neuronal expression of an ecdysone nuclear receptor that triggered neurite remodeling following the late-larval ecdysone peak. Thus glia orchestrate developmental neural remodeling not only by engulfment of unwanted neurites but also by enabling neuron remodeling.

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PubMed Central ID
PMC3337551 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Nat. Neurosci.
    Title
    Nature Neuroscience
    Publication Year
    1998-
    ISBN/ISSN
    1097-6256
    Data From Reference