Reference Report

Reference
Citation	Seong, K.H., Li, D., Shimizu, H., Nakamura, R., Ishii, S. (2011). Inheritance of Stress-Induced, ATF-2-Dependent Epigenetic Change. Cell 145(7): 1049--1061. (Export to RIS)
FlyBase ID	FBrf0214019
Publication Type	Research paper
PubMed ID	21703449
PubMed Abstract	Atf1, the fission yeast homolog of activation transcription factor-2 (ATF-2), contributes to heterochromatin formation. However, the role of ATF-2 in chromatin assembly in higher organisms remains unknown. This study reveals that Drosophila ATF-2 (dATF-2) is required for heterochromatin assembly, whereas the stress-induced phosphorylation of dATF-2, via Mekk1-p38, disrupts heterochromatin. The dATF-2 protein colocalized with HP1, not only on heterochromatin but also at specific loci in euchromatin. Heat shock or osmotic stress induced phosphorylation of dATF-2 and resulted in its release from heterochromatin. This heterochromatic disruption was an epigenetic event that was transmitted to the next generation in a non-Mendelian fashion. When embryos were exposed to heat stress over multiple generations, the defective chromatin state was maintained over multiple successive generations, though it gradually returned to the normal state. The results suggest a mechanism by which the effects of stress are inherited epigenetically via the regulation of a tight chromatin structure.
DOI	10.1016/j.cell.2011.05.029
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Secondary IDs
Language of Publication	English
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Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Aberrations (3)
	In(1)w^m4 In(3L)BL1 T(1;4)w^m258-21
Alleles (10)
	Atf-2^+t13.6 Atf-2^c06407 Atf-2^{Scer\UAS.T:Zzzz\FLAG} aub^QC42 Ecol\lacZ^Hsp70Bb.-190 Mekk1^Scer\UAS.cIa Mekk1^Ur36 Mpk2¹ Scer\GAL4^Act5C.PU spn-E¹
Constructs (5)
	P{Act5C-GAL4.U} P{Atf-2^+t13.6} P{HS-lacZ.scs} P{UAS-Atf-2.Flag} P{UAS-Mekk1.I}
Genes (14)
	Atf-2 aub CG12498 CG32795 CheB38c Ecol\lacZ His3 Mekk1 Mpk2 Scer\GAL4 spn-E Su(var)205 T:Zzzz\FLAG w
Insertions (2)
	P{HS-lacZ.scs}65E PBac{PB}Atf-2^c06407
Natural transposons (1)
	P-element