Reference Report

Reference
Citation	Araújo, S.J., Casanova, J. (2011). Sequoia establishes tip-cell number in Drosophila trachea by regulating FGF levels. J. Cell Sci. 124(14): 2335--2340. (Export to RIS)
FlyBase ID	FBrf0214024
Publication Type	Research paper
PubMed ID	21693579
PubMed Abstract	Competition and determination of leading and trailing cells during collective cell migration is a widespread phenomenon in development, wound healing and tumour invasion. Here, we analyse this issue during in vivo ganglionic branch cell migration in the Drosophila tracheal system. We identify Sequoia (Seq) as a negative transcriptional regulator of Branchless (Bnl), a Drosophila FGF homologue, and observe that modulation of Bnl levels determines how many cells will lead this migrating cluster, regardless of Notch lateral inhibition. Our results show that becoming a tip cell does not prevent others in the branch taking the same position, suggesting that leader choice does not depend only on sensing relative amounts of FGF receptor activity.
DOI	10.1242/jcs.085613
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Language of Publication	English
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Publication Type	Journal
Abbreviation	J. Cell Sci.
Title	Journal of Cell Science
Publication Year	1966-
ISBN/ISSN	0021-9533
Data from Reference
Alleles (21)
	Avic\GFP^{Scer\FRT.Scer\UAS.T:Uuuu\Myr5} Avic\GFP^{Scer\UAS.m6.T:Btau\MAPT} bnl⁰⁰⁸⁵⁷ bnl^Scer\UAS.cSa Moe^{btl.T:Disc\RFP-mRFP} N^{intra.GS.Scer\UAS} pnt^Δ88 Scer\GAL4^69B Scer\GAL4^btl.PS Scer\GAL4^elav-C155 Scer\GAL4^insc-Mz1407 Scer\GAL4^nullo.PG Scer\GAL4^sca-109-68 Scer\GAL4^sim.PS seq²² seq^C022 seq^Scer\UAS.cBa seq^U5 seq^Z1241 shg² shg^E17B
Constructs (9)
	P{btl-moe.mRFP1} P{GAL4-btl.S} P{GAL4-sim.S} P{nullo-GAL4.G} P{UAS(FRT)GFP-myr} P{UAS-bnl.S} P{UAS-N.intra.GS} P{UAS-seq.B} P{UAS-Tau-GFP.m6}
Genes (9)
	Avic\GFP bnl Moe N pnt Scer\GAL4 seq shg trh
Insertions (4)
	P{GawB}69B P{GawB}elav^C155 P{GawB}insc^Mz1407 P{GawB}sca^109-68