|Citation||Araújo, S.J., Casanova, J. (2011). Sequoia establishes tip-cell number in Drosophila trachea by regulating FGF levels. J. Cell Sci. 124(14): 2335--2340. (Export to RIS)|
|Publication Type||Research paper|
|PubMed Abstract||Competition and determination of leading and trailing cells during collective cell migration is a widespread phenomenon in development, wound healing and tumour invasion. Here, we analyse this issue during in vivo ganglionic branch cell migration in the Drosophila tracheal system. We identify Sequoia (Seq) as a negative transcriptional regulator of Branchless (Bnl), a Drosophila FGF homologue, and observe that modulation of Bnl levels determines how many cells will lead this migrating cluster, regardless of Notch lateral inhibition. Our results show that becoming a tip cell does not prevent others in the branch taking the same position, suggesting that leader choice does not depend only on sensing relative amounts of FGF receptor activity.|
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|All updates||Click here to see a list of all updates to this record from FB2010_08 and on.|
|Language of Publication||English|
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|Abbreviation||J. Cell Sci.|
|Title||Journal of Cell Science|
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