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Colozza, G., Montembault, E., Quénerch'du, E., Riparbelli, M.G., D'Avino, P.P., Callaini, G. (2011). Drosophila nucleoporin Nup154 controls cell viability, proliferation and nuclear accumulation of Mad transcription factor.  Tissue Cell 43(4): 254--261.
FlyBase ID
FBrf0214248
Publication Type
Research paper
Abstract

Nuclear Pore Complexes (NPCs) are involved in the regulation of nucleo-cytoplasmic trafficking. Drosophila Nup154 encodes a nucleoporin component of the NPC that is expressed in high proliferating tissues such as germ cells. Hypomorphic mutations in this gene cause male and female sterility and reduction of cell proliferation in the adult fly. Here, we present evidences of a decrease in the number of spermatogonial cells in Nup154 mutants, caused both by increased cell death and reduced cell proliferation. Furthermore, we also found that RNAi-mediated depletion of Nup154 in cultured cells prevented nuclear accumulation of the transcription factor Mothers against Dpp (Mad), suggesting a possible regulatory role for Nup154 in TGF-β signal transduction. These results were confirmed in vivo on mutant testes where we observed a similar defect in the nuclear accumulation of the co-Smad Medea.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Tissue Cell
    Title
    Tissue & cell
    Publication Year
    1969-
    ISBN/ISSN
    0040-8166
    Data From Reference
    Genes (3)