|Citation||Zhang, Z., Pugh, B.F. (2011). Genomic Organization of H2Av Containing Nucleosomes in Drosophila Heterochromatin. PLoS ONE 6(6): e20511. (Export to RIS)|
|Publication Type||Research paper|
|PubMed Abstract||H2Av is a versatile histone variant that plays both positive and negative roles in transcription, DNA repair, and chromatin structure in Drosophila. H2Av, and its broader homolog H2A.Z, tend to be enriched toward 5' ends of genes, and exist in both euchromatin and heterochromatin. Its organization around euchromatin genes and other features have been described in many eukaryotic model organisms. However, less is known about H2Av nucleosome organization in heterochromatin. Here we report the properties and organization of individual H2Av nucleosomes around genes and transposable elements located in Drosophila heterochromatic regions. We compare the similarity and differences with that found in euchromatic regions. Our analyses suggest that nucleosomes are intrinsically positioned on inverted repeats of DNA transposable elements such as those related to the "1360" element, but are not intrinsically positioned on retrotransposon-related elements.|
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|Language of Publication||English|
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|Natural transposons (10)|