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Citation
Chtarbanova, S., Imler, J.L. (2011). Microbial sensing by toll receptors: a historical perspective.  Arterioscler. Thromb. Vasc. Biol. 31(8): 1734--1738.
FlyBase ID
FBrf0214443
Publication Type
Review
Abstract

The family of Toll-like receptors plays an essential role in the induction of the immune response. These receptors sense the presence of microbial ligands and activate the nuclear factor-κB transcription factor. We review the key studies that led from the formulation of the concept of pattern recognition receptors to the characterization of Toll-like receptors, insisting on the important role played by the model organism Drosophila melanogaster and on the increasing evidence connecting these receptors to cardiovascular disease.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Arterioscler. Thromb. Vasc. Biol.
    Title
    Arteriosclerosis, thrombosis, and vascular biology
    ISBN/ISSN
    1079-5642 1524-4636
    Data From Reference
    Genes (16)