Reference Report

Reference
Citation	Jiang, Y., Scott, K.L., Kwak, S.J., Chen, R., Mardon, G. (2011). Sds22/PP1 links epithelial integrity and tumor suppression via regulation of myosin II and JNK signaling. Oncogene 30(29): 3248--3260. (Export to RIS)
FlyBase ID	FBrf0214488
Publication Type	Research paper
PubMed ID	21399659
PubMed Abstract	Loss of epithelial integrity often correlates with the progression of malignant tumors. Sds22, a regulatory subunit of protein phosphatase 1 (PP1), has recently been linked to regulation of epithelial polarity in Drosophila. However, its role in tumorigenesis remains obscure. In this study, using Drosophila imaginal tissue as an in vivo model system, we show that sds22 is a new potential tumor suppressor gene in Drosophila. Without sds22, cells lose epithelial architecture, and become invasive and tumorigenic when combined with Ras overexpression; conversely, sds22 overexpression can largely suppress tumorigenic growth of Ras(V12)scrib(-/-) mutant cells. Mechanistically, we show that sds22 prevents cell invasion and metastasis by inhibiting myosin II and Jun N-terminal kinase (JNK) activity downstream of PP1. Loss of this inhibition causes cells to lose epithelial organization and promotes cell invasion. Finally, human Sds22 is focally deleted and downregulated in multiple carcinomas, and this downregulation correlates with tumor progression, suggesting that sds22 inactivation may contribute to tumorigenesis and metastatic potential in human cancers via a similar mechanism.
DOI	10.1038/onc.2011.46
Related Publication(s)
Supplementary material	Supplementary Figure S1. [FBrf0214679]
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Oncogene
Title	Oncogene
Publication Year	1987-
ISBN/ISSN	0950-9232
Data from Reference
Alleles (22)
	flw^GD15008 flw^{Scer\UAS.T:Ivir\HA1} Pp1-87B^87Bg-3 Pp1-87B^{Scer\UAS.T:Ivir\HA1} puc^Scer\UAS.cMa Ras85D^V12.Scer\UAS Scer\GAL4^Act.PU Scer\GAL4^ey.PU Scer\GAL4^ptc-559.1 scrib⁶⁷³ sds22^e00975 sds22^GD11788 sds22^Scer\UAS.cJa sds22^Δ1.8 sds22^Δ1.83 sds22^Δ2.2 sds22^Δ2.3 sds22^Δ2.8 sqh^DD.Scer\UAS sqh^GD1695 Timp^Scer\UAS.cPa zip^GD1566
Constructs (12)
	P{ey-GAL4.U} P{GD1566} P{GD1695} P{GD11788} P{GD15008} P{UAS-flw.HA} P{UAS-Pp1-87B.HA} P{UAS-puc.M} P{UAS-Ras85D.V12} P{UAS-sds22.J} P{UAS-sqh.DD} P{UAS-Timp.P}
Genes (16)
	ci dlg1 egr elav flw Mmp1 Pp1-87B puc Ras85D Scer\GAL4 scrib sds22 shg sqh Timp zip
Insertions (1)
	P{GawB}ptc^559.1
Natural transposons (1)
	P-element