Reference Report

Reference
Citation	Wen, Y., Parrish, J.Z., He, R., Zhai, R.G., Kim, M.D. (2011). Nmnat exerts neuroprotective effects in dendrites and axons. Mol. Cell. Neurosci. 48(1): 1--8. (Export to RIS)
FlyBase ID	FBrf0214616
Publication Type	Research paper
PubMed ID	21596138
PubMed Abstract	Dendrites can be maintained for extended periods of time after they initially establish coverage of their receptive field. The long-term maintenance of dendrites underlies synaptic connectivity, but how neurons establish and then maintain their dendritic arborization patterns throughout development is not well understood. Here, we show that the NAD synthase Nicotinamide mononucleotide adenylyltransferase (Nmnat) is cell-autonomously required for maintaining type-specific dendritic coverage of Drosophila dendritic arborization (da) sensory neurons. In nmnat heterozygous mutants, dendritic arborization patterns of class IV da neurons are properly established before increased retraction and decreased growth of terminal branches lead to progressive defects in dendritic coverage during later stages of development. Although sensory axons are largely intact in nmnat heterozygotes, complete loss of nmnat function causes severe axonal degeneration, demonstrating differential requirements for nmnat dosage in the maintenance of dendritic arborization patterns and axonal integrity. Overexpression of Nmnat suppresses dendrite maintenance defects associated with loss of the tumor suppressor kinase Warts (Wts), providing evidence that Nmnat, in addition to its neuroprotective role in axons, can function as a protective factor against progressive dendritic loss. Moreover, motor neurons deficient for nmnat show progressive defects in both dendrites and axons. Our studies reveal an essential role for endogenous Nmnat function in the maintenance of both axonal and dendritic integrity and present evidence of a broad neuroprotective role for Nmnat in the central nervous system.
DOI	10.1016/j.mcn.2011.05.002
Related Publication(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Mol. Cell. Neurosci.
Title	Molecular and Cellular Neurosciences
Publication Year	1990-
ISBN/ISSN	1044-7431
Data from Reference
Alleles (9)
	Avic\GFP^6.E.ppk Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Nmnat^Scer\UAS.cZa Nmnat^WR.Scer\UAS Nmnat^Δ4790-2 Scer\GAL4^21-7 Scer\GAL4^elav-C155 Scer\GAL4^ppk.PG wts^x1
Constructs (5)
	P{ppk-EGFP.6} P{ppk-GAL4.G} P{UAS-mCD8::GFP.L} P{UAS-Nmnat.WR} P{UAS-Nmnat.Z}
Genes (5)
	Avic\GFP Mmus\Cd8a Nmnat Scer\GAL4 wts
Insertions (2)
	P{GAL4}21-7 P{GawB}elav^C155