Reference Report

Reference
Citation	Tong, C., Ohyama, T., Tien, A.C., Rajan, A., Haueter, C.M., Bellen, H.J. (2011). Rich Regulates Target Specificity of Photoreceptor Cells and N-Cadherin Trafficking in the Drosophila Visual System via Rab6. Neuron 71(3): 447--459. (Export to RIS)
FlyBase ID	FBrf0214681
Publication Type	Research paper
PubMed ID	21835342
PubMed Abstract	Neurons establish specific synaptic connections with their targets, a process that is highly regulated. Numerous cell adhesion molecules have been implicated in target recognition, but how these proteins are precisely trafficked and targeted is poorly understood. To identify components that affect synaptic specificity, we carried out a forward genetic screen in the Drosophila eye. We identified a gene, named ric1 homologue (rich), whose loss leads to synaptic specificity defects. Loss of rich leads to reduction of N-Cadherin in the photoreceptor cell synapses but not of other proteins implicated in target recognition, including Sec15, DLAR, Jelly belly, and PTP69D. The Rich protein binds to Rab6, and Rab6 mutants display very similar phenotypes as the rich mutants. The active form of Rab6 strongly suppresses the rich synaptic specificity defect, indicating that Rab6 is regulated by Rich. We propose that Rich activates Rab6 to regulate N-Cadherin trafficking and affects synaptic specificity.
DOI	10.1016/j.neuron.2011.06.040
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Neuron
Title	Neuron
Publication Year	1988-
ISBN/ISSN	0896-6273
Data from Reference
Alleles (16)
	Avic\GFP^E.Rh6 CadN⁴⁰⁵ CadN^Δ14 Liprin-α^E Rab6^D23D Rab6^{Q71L.Scer\UAS.P\T.T:Avic\GFP-YFP} Rab6^{T26N.Scer\UAS.T:Avic\GFP-YFP} Rich¹ Rich² Rich^+t7.5 Rich^T:Ivir\HA1 Scer\FLP1^ey.3.5.hs Scer\FLP1^ey.PN Scer\GAL4^Act5C.PP Scer\GAL4^Pan-R7 Syt1^{Scer\UAS.T:Avic\GFP-EGFP}
Constructs (10)
	P{ey-FLP.3.5} P{ey-FLP.N} P{GAL4-Act5C(-FRT).P} P{Pan-R7-GAL4} P{Rh6-EGFP.P} P{UASp-YFP.Rab6.Q71L} P{UAS-syt.eGFP} P{UAST-YFP.Rab6.T26N} PBac{HA-Rich} PBac{Rich7.5}
Genes (20)
	Avic\GFP boca CadN CG1116 chp Glg1 GM130 jeb Lar Liprin-α Ptp69D Rab6 Rh6 Rich Scer\FLP1 Scer\GAL4 sec15 Syt1 Syx16 T:Ivir\HA1
Insertions (5)
	P{GT1}BG02493 P{GT1}CG11226^BG01780 PBac{HA-Rich}VK00037 PBac{Rich7.5}VK00037 PBac{y⁺-attP-3B}VK00037
Natural transposons (1)
	Tni\piggyBac
Polypeptides (1)
	Rich^T:Ivir\HA1XP
Transcripts (1)
	Avic\GFP^E.Rh6RA