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Ayyub, C. (2011). Cullin-5 and cullin-2 play a role in the development of neuromuscular junction and the female germ line of Drosophila.  J. Genet. 90(2): 239--249.
FlyBase ID
FBrf0214802
Publication Type
Research paper
Abstract

Cullins confer substrate specificity to E3-ligases which are multi-protein complexes involved in ubiquitin-mediated protein degradation or modification. There are six cullin genes in Drosophila melanogaster. We have raised an antibody against Cul-5 and demonstrated that it expresses in neuronal and non-neuronal cells throughout development. In the embryonic tracheal system, Cul-5 is enriched at fusion sites together with E-Cadherin and Fasciclin III. Mutations of cul-5 do not affect tracheal development but do show defects in the organization of synaptic boutons at the larval neuromuscular junction where the protein is expressed in a subset of motoneuron terminals. Loss of function of another cullin gene 'cul-2' results in similar defects at the larval neuromuscular junction although cul-2;cul-5 double mutants do not show an enhanced phenotype. Both cul-2 and cul-5 mutants show similar aberrations in the development of female germ line. Our results suggest that both of these cullin proteins participate in similar developmental processes.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    J. Genet.
    Title
    Journal of Genetics
    Publication Year
    1910-
    ISBN/ISSN
    0022-1333
    Data From Reference
    Aberrations (1)
    Alleles (8)
    Gene Groups (1)
    Genes (12)
    Insertions (5)
    Transgenic Constructs (2)
    Transcripts (1)