Reference Report

Reference
Citation	McKechnie, S.W., Blacket, M.J., Song, S.V., Rako, L., Carroll, X., Johnson, T.K., Jensen, L.T., Lee, S.F., Wee, C.W., Hoffmann, A.A. (2010). A clinally varying promoter polymorphism associated with adaptive variation in wing size in Drosophila. Mol. Ecol. 19(4): 775--784. (Export to RIS)
FlyBase ID	FBrf0214827
Publication Type	Research paper
PubMed ID	20074315
PubMed Abstract	Body size often shows adaptive clines in many ectotherms across altitude and latitude, but little is known about the genetic basis of these adaptive clines. Here we identify a polymorphism in the Dca (Drosophila cold acclimation) gene in Drosophila melanogaster that influences wing size, affects wing:thorax allometry and also controls a substantial proportion of the clinal wing-size variation. A polymorphism in the promoter region of Dca had two common alleles showing strong reciprocal clinal variation in frequency with latitude along the east coast of Australia. The Dca-237 allele increased towards the tropics where wing size is smaller. A within-population association study highlighted that an increase in the frequency of this allele decreased wing size but did not influence thorax size. A manipulated increase in the level of expression of Dca achieved through UAS-GAL4 was associated with a decrease in wing size but had no effect on thorax size. This was consistent with higher Dca expression levels in family lines with higher frequency of the Dca-237 allele. Genetic variation in the promoter region of the Dca gene appears to influence adaptive size variation in the eastern Australian cline of Drosophila melanogaster and accounts for more than 10% of the genetic variation in size within and between populations.
DOI	10.1111/j.1365-294X.2009.04509.x
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Secondary IDs
Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Mol. Ecol.
Title	Molecular Ecology
Publication Year	1992-
ISBN/ISSN	0962-1083
Data from Reference
Aberrations (1)
	In(3R)P
Alleles (5)
	Scer\GAL4^tub.PU smp-30²³⁷ smp-30²⁴⁷ smp-30^Scer\UAS.cMa w^+mC
Constructs (2)
	P{tub-GAL4.U} P{UAS-smp-30.M}
Genes (3)
	Scer\GAL4 smp-30 w
Natural transposons (1)
	P-element